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Functional changes of masticatory and swallowing movements by aging and cognitive disorder

衰老和认知障碍导致的咀嚼和吞咽运动的功能变化

基本信息

批准号：
15591972
负责人：
YOSHINO Kenichi
金额：
$ 1.92万
依托单位：
Kyushu Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

While the monkeys performed tongue movement, mastication and swallowing, we recorded the neuronal activity from primary motor cortex (MI), primary somatosensory cortex (SI) and cortical masticatory area (CMA) defined by ICMS. After the sufficient neuronal activities were recorded from these areas, the monkeys were trained to perform the visually guided cognitive task. Then, we recorded the 700 neuronal activities from these areas. The tongue movement related activities were showed in 71%, 61% and 15% neurons, the masticatory related activities were shown in 81%, 83% and 88%, the swallowing related activities were shown in 26%, 0% and 55% neurons at MI, SI and CMA, respectively. In the neurons which showed the tongue movement related activities, we compared their activities before and after acquisition of the cognitive task. Before the acquisition, the tongue movement related activities were shown in 23%, 25% and 40% in MI, SI and CMA, respectively. In the other hand, after the acquisition, these activities were shown in 79%, 54% and 35% in MI, SI and CMA, respectively. The ratio of the MI and SI neuron with tongue movement related activities significantly increased after acquisition of the cognitive task. The findings suggest that the face area in MI, SI and CMA may contribute to the behavioral control of the tongue movement, mastication and swallowing. In addition, the finding that the MI and SI neurons with tongue movement related activities showed the changes after the acquisition suggests that the training of orofacial movements may promote the plasticity of the neuron and elicit the activation of the brain.

在进行舌头运动、咀嚼和吞咽时，我们记录了ICMS定义的初级运动皮质（MI）、初级体感皮质（SI）和皮质咀嚼区（CMA）的神经元活动。在这些区域记录到足够的神经元活动后，训练猴子执行视觉引导的认知任务。然后，我们记录了来自这些区域的700个神经元的活动。在MI、SI和CMA分别有71%、61%和15%的神经元显示舌动相关活动，81%、83%和88%的神经元显示咀嚼相关活动，26%、0%和55%的神经元显示吞咽相关活动。在舌头运动相关的神经元中，我们比较了它们在习得认知任务前后的活动。习得前，舌动相关活动在MI、SI和CMA中分别占23%、25%和40%。另一方面，收购后，这些活动在MI、SI和CMA中分别占79%、54%和35%。习得认知任务后，与舌动相关活动的MI神经元和SI神经元比例显著增加。研究结果表明，MI、SI和CMA的面部区域可能对舌头运动、咀嚼和吞咽的行为控制有贡献。此外，与舌头运动相关的MI和SI神经元在习得后出现了变化，这表明口面部运动的训练可能促进了神经元的可塑性，引发了大脑的激活。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

正常者における歯根膜知覚に対する脳機能評価-fMRIによる解析-

正常人牙周膜感知的脑功能评估 - 使用功能磁共振成像进行分析 -

DOI：
发表时间：
2005
期刊：
北九州医工学術雑誌 16
影响因子：
0
作者：
森本泰宏
通讯作者：
森本泰宏

Properties plasticity of the primate somatosensory and motor cortex related to Orofacial sensorimotor function

与口面部感觉运动功能相关的灵长类体感和运动皮层的特性可塑性

DOI：
发表时间：
2005
期刊：
Clinical and Experimental Pharmacology and Physiology 32
影响因子：
0
作者：
Sessle;B. J.
通讯作者：
B. J.

The role of the brain for feeding behavior. In : N. Amano (Ed.), The Book of Central and Peripheral Nervous System for Dentist

大脑在进食行为中的作用。

DOI：
发表时间：
2005
期刊：
Quintessence Publishing CO., Ltd.
影响因子：
0
作者：
Yoshino;K
通讯作者：
K

Imaging study for perception of occlusion in periodontal ligament by using fMRI

牙周膜咬合感知的功能磁共振成像研究

DOI：
发表时间：
2005
期刊：
J. Kitakyushu Medical and Engineering Cooperative Association 16
影响因子：
0
作者：
Morimoto;Y.;Yoshino;K.;Ando;H.;Shiiba;S.;Sakamoto;E.;Tanaka;T.;Kito;S.;Hatano;K.;Kawagishi;S.;Masumi;S.;Nakanishi;0.;Matsufuji;Y.;Ohba;T.
通讯作者：
T.

歯科臨床に役立つ脳と神経の話

谈论对牙科临床实践有用的大脑和神经