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Effects of Biofilm Activities and Dental Resin Composite Compositions on the Deve

生物膜活性和牙科树脂复合组合物对开发的影响

基本信息

批准号：
8509662
负责人：
Clifton M Carey
金额：
$ 30.13万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-10 至 2016-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8509662
关键词：
Agreement American Area Biological Factors Bioreactors Charge Chemicals Composite Dental Resin Country Defect Dental Enamel Dental Pellicle Dental caries Dentin Dentists Dependence Development Environment Enzymes Etiology Evaluation Exposure to Failure Fluorides Fourier Transform Fracture Goals Ions Lead Length Lesion Life MALDI-TOF Mass Spectrometry Maps Measures Methods Microbe Microbial Biofilms Microradiography Microscopic Minerals Modeling Nuclear Magnetic Resonance Nutrient Oral Plant Resins Polarization Microscopy Process Production Property Role Salivary Sampling Scanning Electron Microscopy Secondary to Services Shapes Simulate Spectrometry Spectroscopy, Fourier Transform Infrared Staining method Stains Streptococcus mutans Stress Surface Testing Thin Layer Chromatography Time Tooth structure Width Work X-Ray Computed Tomography Xenobiotics analytical method base composite restoration cost crosslink demineralization density dental resin esterase interfacial macromolecule novel polymerization shrinkage prevent public health relevance remineralization restoration restorative dentistry simulation success tooth surface

项目摘要

DESCRIPTION (provided by applicant): The primary objectives of this project are to better understand the factors that lead to the development of secondary caries and to identify strategies to increase the service life of resin composite restorations. Restoration replacements due to secondary caries occupies a large portion of the dentist's practices. In 1999, 86 million composites were placed by dentists in this country and 122.7 million in 2006. The average replacement time is now only 5.7 years. Significant improvements in the long-term integrity of so many restorations could save the American people (by reducing costs of replacing restorations) many times the amount of money required to support this work. There is tremendous significance in the successful pursuit of this endeavor to benefit so many millions of people. We propose to study the effects of biofilm activity and dental resin composite compositions on the development of secondary caries. We will use a bioreactor model that utilizes conditions found in the oral environment to understand the role of microbial biofilms, salivary pellicles, and cyclic loading in the processes of secondary caries formation. While the bioreactor model establishes the conditions for the cyclic remineralization/demineralization attacks, we will use a variety of oral-simulating challenges and analytical methods to assess their effects on composite-restored teeth. We hypothesize that major contributors to defects at restoration margins include: interfacial stresses from contractions induced by polymerization shrinkage of resins, salivary esterases, acidogenic microbe-generated biofilms, and deformations from cyclic loading and oral thermal fluctuations. These can lead to subsequent staining, secondary caries, fractures, or other problems. The long-term goals of this project are to identify and prepare an optimally cross-linking composite composition resin that can restore defective teeth and defy environmental degradation (Aim 1); determine the effects of polymerization shrinkage on the development of degradation at the tooth-composite interface (Aim 2); understand the roles of salivary pellicles and microbial biofilms in the etiology of secondary caries' association with composite restorations (Aim 3); and develop beneficial biofilms in synergy with fluoride therapies that have the potential of retarding the onset of secondary caries (Aim 4). Our goal is to understand the physical, chemical and biological factors that determine the length of time a restoration lasts. With this understanding, we will develop more stable resin-based composites and methods to prevent the decay that limits the success of composite restorations. PUBLIC HEALTH RELEVANCE: This project is focused on developing strategies to increase the service life of resin composite restorations. Our goal is to understand the physical, chemical and biological factors that determine the length of time a restoration lasts. With this understanding, we will develop more stable resin-based composites and methods to prevent the decay that limits the success of composite restorations.

描述(由申请人提供)：本项目的主要目标是更好地了解导致继发性龋齿发展的因素，并确定延长树脂复合修复体使用寿命的策略。由于继发性龋齿而进行的修复替换占据了牙医诊所的很大一部分。1999年，这个国家的牙医放置了8600万个复合体，2006年为1.227亿个。平均更换时间现在只有5.7年。在如此多修复的长期完整性方面的重大改进可以节省美国人民(通过减少更换修复的成本)数倍于支持这项工作所需的资金。这项造福数百万人的努力的成功追求具有巨大的意义。我们建议研究生物膜活性和牙科树脂复合成分对继发性龋病发生的影响。我们将使用一个生物反应器模型，该模型利用口腔环境中的条件来了解微生物生物膜、唾液膜和循环负荷在继发性龋病形成过程中的作用。虽然生物反应器模型为周期性再矿化/脱矿攻击奠定了条件，但我们将使用各种口腔模拟挑战和分析方法来评估它们对复合修复牙齿的影响。我们假设，导致修复边缘缺陷的主要因素包括：树脂聚合收缩引起的界面应力，唾液酯酶，产酸微生物生物膜，以及循环加载和口腔热波动造成的变形。这可能会导致随后的染色、继发性龋齿、骨折或其他问题。该项目的长期目标是确定和制备一种能够修复有缺陷的牙齿并防止环境退化的最佳交联型复合树脂(目标1)；确定聚合收缩对牙齿-复合材料界面退化发展的影响(目标2)；了解唾液膜和微生物生物膜在与复合修复体相关的继发性龋病病因学中的作用(目标3)；开发与氟化物疗法协同作用的有益生物膜，有可能延缓继发性龋齿的发生(目标4)。我们的目标是了解决定修复持续时间的物理、化学和生物因素。有了这一认识，我们将开发更稳定的树脂基复合材料和方法，以防止限制复合修复体成功的腐蚀。公共卫生相关性：该项目的重点是制定策略，以延长树脂复合修复体的使用寿命。我们的目标是了解决定修复持续时间的物理、化学和生物因素。有了这一认识，我们将开发更稳定的树脂基复合材料和方法，以防止限制复合修复体成功的腐蚀。