Molecular mechanisms underlying progenitor migration following methylmercury exposure in the developing brain

为了了解甲基汞(MeHg)对发育中的大脑皮层神经元和神经胶质前体迁移的影响，我们研究了胎儿或新生儿给予甲基汞(MeHg)后端脑外套膜基因表达的变化，其中组织病理学证实了甲基汞对神经前体迁移的明显破坏。我们将提取的mRNA样本应用于两种在不同生物技术概念下制作的DNA微阵列。然后，根据生物信息学的方法对大量数据进行分析。我们选择了11个分子，它们可以被认为是与甲基汞神经毒性的迁移障碍密切相关的特定分子线索的候选者。

To understand the effects of methylmercury (MeHg) on neuronal and glial progenitor migration in the developing cerebral cortex, we examined profile alterations in gene expression in the telencephalic mantle following fetal or neonatal administration of MeHg, wher an apparent disrupition of the progenitor migration had been elucidated histopathologically. We applied extracted mRNA samples to two kinds of DNA microarrays, which had been made under different biotechnological concepts. Then, we performed analysis of the plenty of data according to the bioinformatics methodologies. We selected 11 molecules, which could be regarded as candidates of specific molecular cues closely associated with the migration disturbance underlying MeHg neurotoxicity.