The effect of shift work on the onset of life-style related diseases ; Large longitudinal study for 14 years

生活方式相关疾病定义为受饮食习惯、运动习惯、休息、吸烟习惯和饮酒习惯影响的一组疾病，包括2型糖尿病、肥胖、高脂血症、高尿酸血症、缺血性心脏病、结肠癌、高血压、肺鳞状细胞癌、慢性支气管炎、肺气肿、另一方面，近年来，随着生活方式的改变，24小时服务的增加，轮班制的企业也在增加。劳动部报告说，2005年，22.7%的日本公司雇用轮班工人，包括夜班工人。工作环境是形成日常习惯的一个重要因素，倒班工作被认为比白天工作对身体和精神的压力更大，基于这样的背景，我们认为， 关于我们 为全面了解倒班工作与生活方式相关疾病的关系，对高血压、糖尿病、高脂血症、肥胖、高尿酸血症、肝功能异常、脑血管疾病和缺血性心脏病作为生命的一部分，与工作方式有关的疾病，并从生活方式因素和工作条件方面纵向显示倒班工作对各种疾病的影响，倒班工作与生活方式有关，高血压（OR：1.123 CI：1.029-1.225）、舒张期高血压（OR：1.361 CI：1.192-1.555）、高胆固醇血症（OR：1.124 CI：1.030-1.226）和BMI增加5%（OR：1.129 CI：1.048-1.217）。倒班对脑血管病的发病有负性影响（OR：0.412 CI：0.186-0.912）。此外，吸烟还能显著升高血清总胆固醇水平（OR：1.124CI：1.026 ~ 1.231），提示轮班工作可影响高血压、高胆固醇血症和体重增加的发生。少

Life-style related diseases are defined as a group of diseases which are affected by dietary habits, exercise habits, rest, smoking habits and drinking habit and that includes Type 2 Diabetes Mellitus, obesity, hyperlipidemia, hyperuricemia, ischemic heart disease, colon cancer, hypertension, squamous cell carcinoma of the lung, chronic bronchitis, pulmonary emphysema, alcoholic liver dysfunction and periodontal disease and so on. On the other hand, the number of companies using shift workers has increased recently because around-the-clock services associated with changing lifestyles have increased, and thus more workers are shift workers. The Ministry of Labor reported that 22.7% of Japanese companies employed shift workers including night workers in 2005. A working condition is a major factor that forms daily habits and shift work are considered to have greater strain, physically and mentally, than daytime work.Based on such background, we have thought that it is significant to manif … More est the relationship between shift work and lifestyle related diseases comprehensively and performed the present study.The present study dealt with hypertension, diabetes Mellitus, hyperlipidemia, obesity, hyperuricemia, liver dysfunction, cerebrovascular disease and ischemic heart disease as life-style related diseases and manifested the effect of shift work on each diseases longitudinally considering lifestyle factors and working conditions.Shift work was significantly related to hypertension (OR:1.123 CI:1.029-1.225), diastolic hypertension (OR:1.361 CI:1.192-1.555), hypercholesterolemia (OR:1.124 CI:1.030-1.226) and an increase of BMI by 5% (OR:1.129 CI:1.048-1.217). On the other hand, the onset of cerebrovascular disease was negatively effected by shift work (OR:0.412 CI:0.186-0.912). Furthermore, smoking habits significantly increased the level of serum total cholesterol (OR:1.124 CI:1.026-l.231).The present study revealed that shift work could effect on the onset of hypertension, hypercholesterolemia and weight gain. Less