A case-control study on atrophic gastritis and gastric cancer using stored sera and genome DNA.

使用储存的血清和基因组 DNA 进行萎缩性胃炎和胃癌的病例对照研究。

• 批准号: 17590695
• 负责人: SUZUKI Gen
• 金额: $ 2.3万
• 依托单位: National Institute of Public Health
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590695/
• 关键词: case control study; gastric cancer; H.pylori IgG; CagA; dose; smoking; atrophic gastritis; 症例対照研究; cag A; H.pylori; 放射線

Background ＆ Aims : To investigate, firstly, the relationship between radiation dose and gastric cancer after full adjustment of various risk factors, and secondly to investigate the Gig antibody titer against Helicobacter pylori CagA as a risk factor for future noncardia gastric cancer. Methods : A nested case-control study was performed in the longitudinal cohort of atomic bomb survivors using stored sera before diagnosis (mean=2.3years). Enrolled were 299 cancer cases and 3 controls per case selected from cohort members matched on age, gender, city, time and type of serum storage, and counter-matched on radiation dose. As to 172 cases and 1071 controls, we also used stored sera 8.6 years before diagnosis. Results : H.pylori IgG-seropositive with CagA IgG_low titer was the strongest risk factor for noncardia gastric cancer (relative risk (RR)=3.9,95%C.I. 2.1-7.0, p<0.001), especially for intestinal type tumor (RR=9.9, 95%C.I. 3.5,27.4, p<0.001), compared with other risk factors, H.pylori IgG-seropositive with CagA Gig negative (RR=2.2, 95%C.I. 1.3-3.9, p=0.0052), H.pylori IgG-seropositive with CagA IgG_high titer (RR=2.0,95%C.I. 1.3-3.2, p=0.0022), chronic atrophic gastritis (RR=2.4,95%C.I. 1.8-3.3, p<0.001), current smoking (RR=2.3,95%C.I 1.4-3.5, p<0.001) or radiation dose (RR=2.1,95%C.I. 1.2-3.1, p=0.00193). Current smoking showed significantly higher risk for diffuse type than intestinal type tumors (p=0.0372). Radiation risk was significant only for non-smokers, all noncardia and diffuse type gastric cancers. Low antibody titer to CagA was not due to the rapid progression of atrophic gastritis, because the progression rate did not differ between low titer and high titer groups. Conclusions : A low CagA IgG_titer is a useful biomarker to identify a high risk group and it also provides a clue to understanding host-pathogen interaction.

背景和目标：探讨在充分调整各种危险因素后，辐射剂量与胃癌的关系，并探讨幽门螺杆菌CagA Gig抗体滴度作为未来非贲门部胃癌的危险因素。研究方法：采用巢式病例对照研究方法，对原子弹爆炸幸存者进行了诊断前（平均= 2.3年）储存血清的纵向队列研究。入组了299例癌症病例和3例对照，每例病例选自年龄、性别、城市、时间和血清储存类型匹配的队列成员，并在辐射剂量上配对。对172例病例和1071例对照者，也使用了诊断前8.6年的血清。结果：H.pylori IgG阳性、CagA IgG低滴度是非贲门部胃癌最强的危险因素（RR = 3.9，95%C. I.）。2.1-7.0，p<0.001），尤其是肠型肿瘤（RR=9.9，95%C.I. 3.5，27.4，p<0.001），与其他危险因素相比，幽门螺杆菌IgG血清阳性且CagA Gig阴性（RR=2.2，95%CI 1.3-3.9，p=0.0052），幽门螺杆菌IgG-血清阳性，CagA IgG_高滴度（RR= 2.0，95%C.I. 1.3-3.2，p=0.0022）、慢性萎缩性胃炎（RR= 2.4，95%C.I. 1.8-3.3，p<0.001）、当前吸烟（RR= 2.3，95%C.I1.4 -3.5，p<0.001）或辐射剂量（RR= 2.1，95%C.I1.4 -3.5，p<0.001）。1.2-3.1，p=0.00193）。目前吸烟显示弥漫型肿瘤的风险显著高于肠型肿瘤（p=0.0372）。辐射风险仅对非吸烟者、所有非贲门癌和弥漫型胃癌有意义。CagA抗体滴度低不是由于萎缩性胃炎的快速进展，因为低滴度和高滴度组之间的进展率没有差异。结论：低CagA IgG_滴度是鉴定高风险组的有用生物标志物，并且它还提供了理解宿主-病原体相互作用的线索。

项目成果

Smoking and alcohol habits as risk factors for benign digestive diseases in a Japanese population : The Radiation Effects Research Foundation Adult Health Study.

吸烟和饮酒习惯是日本人群良性消化系统疾病的危险因素：辐射影响研究基金会成人健康研究。

• 发表时间: 2005
• 期刊: Digestion 71(4)
• 作者: 大久保 豪;他;Yamada M
• 通讯作者: Yamada M

Low-positive antibody titer against Helicobacter pylori CagA may predict future gastric cancer better than simple seropositivity against Helicobacter pylori CagA or against Helicobacter pylori.

与单纯的幽门螺杆菌 CagA 或幽门螺杆菌血清阳性相比，针对幽门螺杆菌 CagA 的低阳性抗体滴度可以更好地预测未来的胃癌。

• 发表时间: 2007
• 期刊: Cancer Epidemiology, Biomarkers ＆ Prevention 16(6)
• 作者: Suzuki G;Cullings H;Fujiwara S;Hattori N;Matsuura S;Hakoda M;Akahoshi M;Kodama K;Tahara E
• 通讯作者: Tahara E

Mortality of rheumatoid arthritis in Japan: a longitudinal cohort study

• DOI: 10.1136/ard.2004.033761
• 发表时间: 2005-10-01
• 期刊: ANNALS OF THE RHEUMATIC DISEASES
• 影响因子: 27.4
• 作者: Hakoda, M;Oiwa, H;Fujiwara, S
• 通讯作者: Fujiwara, S

Feasibility of freeze-dried sera for serological and molecular biological detection of hepatitis B and C viruses

冻干血清用于乙型和丙型肝炎病毒血清学和分子生物学检测的可行性

• 发表时间: 2006
• 期刊: J. Clin. Microbiol. 44
• 作者: Ohashi W;Fujiwara S;Suzuki G;Kishi T;Sora M;Matsuura S;Hakoda M;Yamada M;Chayama K
• 通讯作者: Chayama K

Relationship of hepatocellular carcinoma to soya food consumption: A cohort-based, case-control study in Japan

• DOI: 10.1002/ijc.20897
• 发表时间: 2005-06-10
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Sharp, GB;Lagarde, F;Tokuoka, S
• 通讯作者: Tokuoka, S