The establishment of the novel diagnosis methods based on the analysis of the pathogenesis of the allergic diseases

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Allergic diseases are caused by complex interactions of genetic and environmental factors. We focused on IFN-γ and IL-12, which play pivotal roles in the suppressive system in allergic reactions and searched for genes related to the signal transduction.(1) In this study, based on reports from all over the world including the above-mentioned results, we tried to genetically re-categorize allergy. There are 4 factors for categorization ; (1) antigen recognition site of the HLA class II-peptide-T cell receptor as a determinant of antigen specificity in allergic reactions, (2) B cell response in IgE production, (3) mediator production, and (4) target organs.(2) There is a great inter-individual variation in the pathogenesis of allergy. Since rapid and precise assay is necessary to apply gene polymorphisms to clinical treatment/diagnosis, in other words, to provide tailor-made medicine, an allergy gene diagnosis kit using an invader assay was developed.(3) In future studies, it is necessary to elucidate usefulness of these polymorphisms for the tailor-made medicine in allergic disease.