The changes of renal function after the simultaneous injection of different type of contrast media: experimental study on healthy and diabetes mellitus nephropathy rats

目的：探讨链脲佐菌素诱导的糖尿病肾病大鼠同时注射不同类型造影剂（Gd-DTPA）和Iopamiron （Iopamidol）后肾功能的变化。材料与方法：实验组为健康大鼠和链脲佐菌素诱导的糖尿病肾病大鼠。试验溶液为对比剂混合组（Magnevist+Iopamiron）、生理盐水组、甘露醇组。结果：红细胞压积值未升高。尿量增加组间无显著差异。血清肌酐值短暂升高，随时间延长而下降。血尿氮值无明显升高。肌酐清除率未见明显下降。钠的部分排泄有短暂性增加，但各组间无显著差异。游离水清除率瞬间降低，但各组间无显著差异。结论：链脲佐菌素诱导的糖尿病肾病大鼠同时注射不同类型造影剂对肾功能的影响不严重，且是短暂性的

Objective : to investigate the changes of renal function after the simultaneous injection of different type of contrast media including Magnevist (Gd-DTPA) and Iopamiron (Iopamidol) on healthy and streptozotocin induced diabetes mellitus nephropathy rats.Materials and methods : Experimental groups consist of healthy rats and streptozotocin induced diabetes mellitus nephropathy rats. Test solutions are contrast media mixture group (Magnevist+Iopamiron), physiological saline group, and manitol group.Results : Hematocrit value was not increased. Urine volume was increased without any significant difference among groups. Serum creatinine value was transiently increased, and declined with time. There was no significant increase in blood urine nitrogen value. No significant decrease in Creatinine clearance was observed. Fraction excretion of sodium was transiently increased, while no significant difference was observed among groups. Free water clearance was transiently decreased, while no significant difference was observed among groups.Conclusion : The changes of renal function after the simultaneous injection of different type of contrast media was not serious and transient on healthy and streptozotocin induced diabetes mellitus nephropathy rats