The changes of renal function after the simultaneous injection of different type of contrast media: experimental study on healthy and diabetes mellitus nephropathy rats

同时注射不同类型造影剂后肾功能的变化：健康及糖尿病肾病大鼠的实验研究

• 批准号: 17591294
• 负责人: HAYASHI Hiromitsu
• 金额: $ 1.28万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591294/
• 关键词: Contrast Media; Renal Insufficiency; Interaction; Diabetes Mellitus; Experimental Study; iopamidol; Gd-DTPA; interaction; renal function; experimental study

Objective : to investigate the changes of renal function after the simultaneous injection of different type of contrast media including Magnevist (Gd-DTPA) and Iopamiron (Iopamidol) on healthy and streptozotocin induced diabetes mellitus nephropathy rats.Materials and methods : Experimental groups consist of healthy rats and streptozotocin induced diabetes mellitus nephropathy rats. Test solutions are contrast media mixture group (Magnevist+Iopamiron), physiological saline group, and manitol group.Results : Hematocrit value was not increased. Urine volume was increased without any significant difference among groups. Serum creatinine value was transiently increased, and declined with time. There was no significant increase in blood urine nitrogen value. No significant decrease in Creatinine clearance was observed. Fraction excretion of sodium was transiently increased, while no significant difference was observed among groups. Free water clearance was transiently decreased, while no significant difference was observed among groups.Conclusion : The changes of renal function after the simultaneous injection of different type of contrast media was not serious and transient on healthy and streptozotocin induced diabetes mellitus nephropathy rats

目的：目的：探讨不同类型造影剂（Gd-DTPA和Iopamiron）同时注射对健康大鼠和链脲佐菌素（STZ）糖尿病肾病大鼠肾功能的影响。试验液为对比剂混合液组（美维显+碘帕铁）、生理盐水组、甘露醇组。尿量增加，组间无任何显著差异。血清肌酐值一过性升高，并随时间下降。血尿氮值无明显升高。未观察到肌酐清除率显著降低。钠排泄分数一过性增加，但组间无显著差异。结论：不同造影剂同时注射对正常大鼠和糖尿病肾病大鼠肾功能的影响均不严重，且均为一过性

项目成果

Advances of Diagnostic Imaging Related to Progress in Multidetector-row CT Scanners : Impact on the Evaluation of Vascular Diseases

与多排 CT 扫描仪进展相关的诊断成像进展：对血管疾病评估的影响

• 发表时间: 2005
• 期刊: J Jpn Coll Angiol 45
• 作者: Ohmuraya;M.;東野 博;S.Shimohara;東野 博;M.Ohmuraya;荒木 正健;Kazuhiko Masuda;Hiromitsu Hayashi
• 通讯作者: Hiromitsu Hayashi

Multidetector-rowCT Evaluation of Aortic Disease

主动脉疾病的多排CT评估

• 发表时间: 2005
• 期刊: Radiation Medicine 23
• 作者: Akimoto;T.;Mitsuhashi;N.(6名中6番目);Hiromitsu Hayashi
• 通讯作者: Hiromitsu Hayashi