Functional scaffold with growth factors for artificial organs and biomaterials, with angiogenesis and tissue reconstruction ability

用于人造器官和生物材料的具有生长因子的功能支架，具有血管生成和组织重建能力

• 批准号: 17591353
• 负责人: UETSUKA Yoshio
• 金额: $ 2.24万
• 依托单位: Tokyo Women's Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591353/
• 关键词: angiogenesis; scaffold; reconstruction; collagen; artificial organ; biomaterial; cytokine; wound healing; rabbit; bFGF; 再生医療

One of scaffold selection, collagen is a biocompatible material, however commercially available collagen hemostats are not equally made and cell affinity is different between the products.For wound healing, the combination of cells, cytokines and scaffolds are the important factors to accelerate the healing. During angiogenesis in wound healing in a rabbit ear chamber model, angiogenesis was accelerated with cotton type atelo-collagen fiber, and recombinant human basic fibroblast growth factor (rhbFGF). We hypothesized that collagen fiber might absorb rhbFGF and worked as functional scaffold. This combination work in vivo, we could apply this into artificial organs and biomaterials to obtain angiogenesis and tissue reconstruction, as we plan.

胶原是一种生物相容性良好的材料，但市售胶原止血材料的制备方法不一，对细胞的亲和性也不相同，细胞、细胞因子和支架的结合是促进伤口愈合的重要因素。在兔耳腔模型中，在伤口愈合的血管生成过程中，用棉型末端胶原纤维和重组人碱性成纤维细胞生长因子（rhbFGF）促进血管生成。我们推测胶原纤维可能吸收rhbFGF并作为功能性支架。这种结合在体内起作用，我们可以将其应用到人造器官和生物材料中，以获得血管生成和组织重建，正如我们计划的那样。

项目成果

Pharmacoecomic analysis of cilostazol for the secondary prevention of cerebral infarction

西洛他唑脑梗死二级预防的药理学分析

• 发表时间: 2006
• 期刊: Circulation journal 70
• 作者: Inoue T;Uetsuka Y;et al.
• 通讯作者: et al.

Endothelialization and functional neointima on vascular grafts in humans

人类血管移植物的内皮化和功能性新内膜

• 发表时间: 2005
• 期刊: Ann Thorac Surg 79
• 作者: Sato M;Endo M;et al.;Tomizawa Y;Tomizawa Y
• 通讯作者: Tomizawa Y

Local injection of a sustained-release antiandrogen formulation into a target prostatic site : an experimental study

将缓释抗雄激素制剂局部注射到目标前列腺部位：一项实验研究

• 发表时间: 2007
• 期刊: BJU Int 99(1)
• 作者: Goya N;Gotanda K;Sasaki T;Okada M;Tomizawa Y;Toma H
• 通讯作者: Toma H

Certified perfusionists in Japan

日本认证灌注师

• 发表时间: 2007
• 期刊: J Artif Organs 10(2)
• 作者: Tomizawa Y;Momose N
• 通讯作者: Momose N

心臓不整脈と血栓症

心律失常和血栓形成

• 发表时间: 2005
• 期刊: 感染防止 15
• 作者: Yashimo-Abo A;Satoh T;Abo T;et al.;上塚芳郎
• 通讯作者: 上塚芳郎