Functional scaffold with growth factors for artificial organs and biomaterials, with angiogenesis and tissue reconstruction ability

在支架材料的选择中，胶原是一种生物相容性材料，但市面上的胶原止血剂制作不同，且不同产品之间的细胞亲和力不同。对于创面愈合，细胞、细胞因子和支架的结合是促进愈合的重要因素。在兔耳室创伤愈合的血管生成过程中，棉型阿特罗-胶原纤维和重组人碱性成纤维细胞生长因子(RhbFGF)促进了血管生成。我们推测胶原纤维可能吸收了重组人碱性成纤维细胞生长因子，作为功能性支架。这种结合在体内发挥作用，我们可以将其应用于人工器官和生物材料，以获得我们计划的血管生成和组织重建。

One of scaffold selection, collagen is a biocompatible material, however commercially available collagen hemostats are not equally made and cell affinity is different between the products.For wound healing, the combination of cells, cytokines and scaffolds are the important factors to accelerate the healing. During angiogenesis in wound healing in a rabbit ear chamber model, angiogenesis was accelerated with cotton type atelo-collagen fiber, and recombinant human basic fibroblast growth factor (rhbFGF). We hypothesized that collagen fiber might absorb rhbFGF and worked as functional scaffold. This combination work in vivo, we could apply this into artificial organs and biomaterials to obtain angiogenesis and tissue reconstruction, as we plan.