Stimulated Emission Depletion (STED) Microscope

受激发射损耗 (STED) 显微镜

• 批准号: 465795356
• 金额: --
• 依托单位: Martin-Luther-Universität Halle-Wittenberg
• 依托单位国家: 德国
• 项目类别: Major Research Instrumentation
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 无数据
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/465795356?language=en
• 关键词: Stimulated; Emission; Depletion; STED; Microscope

The proposal for a STED microscope is based on the call for the professorship for Experimental Pharmacology for Natural Sciences at the Martin Luther University Halle-Wittenberg and therefore, essentially supports the establishment of the newly formed research group. STED microscopy strengthens the methodological spectrum of the group. Especially, current and future projects related to RNA binding proteins in inflammatory and malignant diseases as well as pathomechanisms in non-alcoholic fatty liver disease will benefit from high-resolution microscopy. In addition, the planned acquisition will support the call for the professorship for Biopharmacy as well as other research groups of the Institute of Pharmacy, the Institute of Biochemistry and Biotechnology, and the Medical Faculty. STED microscopy displays an excellent technique to study intracellular structures, protein complexes, binding of RNA to RNA bindings proteins and alterations of the respective structures. STED microscopy offers a resolution of <200 nm. As yet, such high-resolution microscopy is not available at the Martin Luther University. Thus, the planned STED microscope would strongly improve the infrastructure for imaging techniques at Martin Luther University.

STED显微镜的建议是基于对马丁路德大学哈雷-维滕贝格自然科学实验药理学教授职位的要求，因此，基本上支持新成立的研究小组的建立。STED显微镜加强了该组的方法谱。特别是，目前和未来的项目相关的RNA结合蛋白在炎症和恶性疾病以及病理机制在非酒精性脂肪肝疾病将受益于高分辨率显微镜。此外，计划中的收购将支持生物制药教授职位以及药学研究所，生物化学和生物技术研究所和医学院的其他研究小组的需求。STED显微镜显示了研究细胞内结构、蛋白质复合物、RNA与RNA结合蛋白的结合以及相应结构的改变的优秀技术。STED显微镜提供<200 nm的分辨率。到目前为止，马丁路德大学还没有这种高分辨率的显微镜。因此，计划中的STED显微镜将大大改善马丁路德大学成像技术的基础设施。