Stimulated Emission Depletion (STED) Microscope

STED 显微镜的提案是基于马丁路德大学哈雷维滕贝格自然科学实验药理学教授职位的呼吁，因此基本上支持新成立的研究小组的建立。 STED 显微镜强化了该小组的方法谱。特别是，当前和未来与炎症和恶性疾病中的RNA结合蛋白以及非酒精性脂肪肝疾病的病理机制相关的项目将受益于高分辨率显微镜。此外，计划中的收购还将支持生物制药学教授职位以及药学研究所、生物化学与生物技术研究所和医学院其他研究小组的需求。 STED 显微镜展示了一种出色的技术来研究细胞内结构、蛋白质复合物、RNA 与 RNA 结合蛋白的结合以及各自结构的改变。 STED 显微镜的分辨率<200 nm。迄今为止，马丁路德大学还没有这种高分辨率的显微镜。因此，计划中的 STED 显微镜将极大地改善马丁路德大学成像技术的基础设施。

The proposal for a STED microscope is based on the call for the professorship for Experimental Pharmacology for Natural Sciences at the Martin Luther University Halle-Wittenberg and therefore, essentially supports the establishment of the newly formed research group. STED microscopy strengthens the methodological spectrum of the group. Especially, current and future projects related to RNA binding proteins in inflammatory and malignant diseases as well as pathomechanisms in non-alcoholic fatty liver disease will benefit from high-resolution microscopy. In addition, the planned acquisition will support the call for the professorship for Biopharmacy as well as other research groups of the Institute of Pharmacy, the Institute of Biochemistry and Biotechnology, and the Medical Faculty. STED microscopy displays an excellent technique to study intracellular structures, protein complexes, binding of RNA to RNA bindings proteins and alterations of the respective structures. STED microscopy offers a resolution of <200 nm. As yet, such high-resolution microscopy is not available at the Martin Luther University. Thus, the planned STED microscope would strongly improve the infrastructure for imaging techniques at Martin Luther University.