Stimulated Emission Depletion (STED) Microscope

关于STED显微镜的建议是基于对马丁·路德大学哈勒-威滕贝格自然科学实验药理学教授职位的呼吁，因此，基本上支持建立新成立的研究小组。STED显微镜加强了该小组的方法论光谱。特别是，目前和未来与炎症和恶性疾病中的RNA结合蛋白以及非酒精性脂肪性肝病的病理机制相关的项目将受益于高分辨率显微镜。此外，计划中的收购将支持对生物制药教授以及药学研究所、生物化学和生物技术研究所以及医学院的其他研究小组的呼吁。STED显微镜展示了一种研究细胞内结构、蛋白质复合体、RNA与RNA结合蛋白质的结合以及各自结构变化的极佳技术。STED显微镜提供了200纳米的分辨率。到目前为止，马丁·路德大学还没有这样的高分辨率显微镜。因此，计划中的STED显微镜将有力地改善马丁·路德大学成像技术的基础设施。

The proposal for a STED microscope is based on the call for the professorship for Experimental Pharmacology for Natural Sciences at the Martin Luther University Halle-Wittenberg and therefore, essentially supports the establishment of the newly formed research group. STED microscopy strengthens the methodological spectrum of the group. Especially, current and future projects related to RNA binding proteins in inflammatory and malignant diseases as well as pathomechanisms in non-alcoholic fatty liver disease will benefit from high-resolution microscopy. In addition, the planned acquisition will support the call for the professorship for Biopharmacy as well as other research groups of the Institute of Pharmacy, the Institute of Biochemistry and Biotechnology, and the Medical Faculty. STED microscopy displays an excellent technique to study intracellular structures, protein complexes, binding of RNA to RNA bindings proteins and alterations of the respective structures. STED microscopy offers a resolution of <200 nm. As yet, such high-resolution microscopy is not available at the Martin Luther University. Thus, the planned STED microscope would strongly improve the infrastructure for imaging techniques at Martin Luther University.