Base-Promoted Oxidative PCET Remote Functionalization (B06)

碱促进氧化 PCET 远程功能化 (B06)

• 批准号: 467053571
• 金额: --
• 依托单位: Institut für Organische Chemie
• 依托单位国家: 德国
• 项目类别: CRC/Transregios
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/467053571?language=en
• 关键词: Base; Promoted; Oxidative; PCET; Remote

The project aims at the improved understanding of the association of base, OH-substrate and photocatalytic oxidant in (oxidative) multisite proton-coupled electron transfer reactions (MS PCET). The identification of the critical interactions within these ternary assemblies, which is sought after in collaboration with spectroscopy, and the modulation of these assembly effects to facilitate PCET should allow for alkoxy radical generation under preferably mild conditions. From a synthetic point of view this in turn should enable versatile photocatalytic remote functionalization of non-activated alcohols, especially with respect to compatibility with multicatalytic settings.

该项目旨在提高对（氧化）多位点质子耦合电子转移反应（MS PCET）中碱，OH-底物和光催化氧化剂之间关系的理解。这些三元组件内的关键相互作用的识别，这是寻求与光谱学合作后，和这些组件的调制效果，以促进PCET应允许烷氧基自由基的产生，优选在温和的条件下。从合成的角度来看，这反过来应该能够实现非活化醇的多功能光催化远程官能化，特别是关于与多催化设置的相容性。