Regulation of MPF activation and Institute of Mitosis

在这组中，从G2到有丝分裂的细胞周期调控从以下方面进行了研究。T: RCC1-Ran循环。他们从哺乳动物细胞中克隆了RanBP2、RanBP1，并从酿酒酵母中克隆了rb1、YRB2和DIS3作为ran结合蛋白。Kikuchi， T.：她分离了G2/M转化所需的新基因TOM1， STO1和STO2。Yoshida.M。他已经鉴定出K-252的靶基因为SRM1。Kobayashi， H.：他研究了Xenopus cyclin A过表达对酿酒酵母细胞周期的影响，发现酿酒酵母在有丝分裂时没有染色体分离。Masumoto， H.: CENP-B的过表达。Sakata， N.：他已经阐明了Mos是MAP激酶级联反应的关键调节因子。Tanaka， K.：他已经确定了包含泛素依赖性蛋白酶体的蛋白质，并克隆了编码这些蛋白质的cDNA。Adachi， Y.：他研究了DNA复制完成和有丝分裂开始之间的关系。

In this group, the cell cycle regulation from G2 to mitosis was investigated from the aspect described as follows.Nishimoto. T : RCC1-Ran cycle. They have cloned RanBP2, RanBP1 from mammalian cells and YRB1, YRB2 and DIS3 from S.cerevisiae, as the Ran-binding protein. Kikuchi, T. : She isolated novel genes, TOM1, STO1 and STO2 required for G2/M transition. Yoshida.M. : He has identified the target gene of K-252, as SRM1. Kobayashi, H. : He has investigated the effect of Xenopus cyclin A overexpression on the cell cycle of S.cerevisiae and found that S.cerevisiae arrested in mitosis without chromosome segregation. Masumoto, H. : Overexpression of CENP-B.Sakata, N. : He has clarified that Mos is a key regulator in the MAP kinase cascade. Tanaka, K. : He has identified proteins comprising the ubiquitin dependent proteasome and cloned the cDNA encoding these proteins. Adachi, Y. : He investigated the relationship between the completion of DNA replication and the initiation of mitosis.