Regulation of MPF activation and Institute of Mitosis

在这一组中，从以下方面研究了从G2到有丝分裂的细胞周期调节。T：RCC 1-运行循环。他们从哺乳动物细胞中克隆了RanBP 2、RanBP 1，从酿酒酵母中克隆了YRB 1、YRB 2和DIS 3，作为Ran结合蛋白。菊池、T.她分离出了G2/M转换所需的新基因TOM 1、STO 1和STO 2。吉田他已经确定了K-252的靶基因，即SRM 1。小林、H.他研究了非洲爪蟾细胞周期蛋白A过表达对酿酒酵母细胞周期的影响，发现酿酒酵母在没有染色体分离的情况下停止有丝分裂。Masumoto，H.：CENP-B的过表达。Sakata，N.：他澄清了Mos是MAP激酶级联反应中的关键调节因子。Tanaka，K.他已经鉴定出包含泛素依赖性蛋白酶体的蛋白质，并克隆了编码这些蛋白质的cDNA。阿达奇，Y.他研究了DNA复制的完成和有丝分裂的开始之间的关系。

In this group, the cell cycle regulation from G2 to mitosis was investigated from the aspect described as follows.Nishimoto. T : RCC1-Ran cycle. They have cloned RanBP2, RanBP1 from mammalian cells and YRB1, YRB2 and DIS3 from S.cerevisiae, as the Ran-binding protein. Kikuchi, T. : She isolated novel genes, TOM1, STO1 and STO2 required for G2/M transition. Yoshida.M. : He has identified the target gene of K-252, as SRM1. Kobayashi, H. : He has investigated the effect of Xenopus cyclin A overexpression on the cell cycle of S.cerevisiae and found that S.cerevisiae arrested in mitosis without chromosome segregation. Masumoto, H. : Overexpression of CENP-B.Sakata, N. : He has clarified that Mos is a key regulator in the MAP kinase cascade. Tanaka, K. : He has identified proteins comprising the ubiquitin dependent proteasome and cloned the cDNA encoding these proteins. Adachi, Y. : He investigated the relationship between the completion of DNA replication and the initiation of mitosis.