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cell cycle regulation

细胞周期调节

基本信息

批准号：
05269103
负责人：
NISHIMOTO Takeharu
金额：
$ 58.82万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05269103/
关键词：
G0 G1 DNA replication Mitosis Map Kinase Cycline cdc2 Ubiquitin G protein コビキチン細胞周期染色体分配 G2 M ライセンス因子プロテアソーム

项目摘要

MAP kinase cascade in the signal transduction pathway : Map kinase has been identified as a kinase which induce phosphorylation to activate maturation prompting factor (MAF) consisting of cdc2 and cyclin B.Drs.Nishida (Kyoto U.) and Sakata (Kyushu U.) clarified that Mos is a key regulator in the MAP kinase cascade.Identification of Licensing factor for DNA replication in S phase : In eukaryote, it is very important that the total genomic DNA is replicated only once in the S phase. To do that it has been assumed that cells possess a factor to license only the signal round of DNA replication in S phase. In this research program, Dr.Takisawa identified the protein factor which allow a single round of DNA replication. It is turned out to be a mammalian homologue of S.cereviae Mcm families.Cyclins in the cell cycle : Cyclins comprise either MPF or SPF with cdc2 or cdks that are so called cell cycle engines. In this context, it is a very important question why cyclins are essential for MPF a … More nd SPF functions. Drs Kobayashi (Kyushu U.) and Kishimoto (Tokyou Engineering U.) investigated the interaction between cdc2 and cyclin B during G2/M transition.Ubiqutin system in the cell cycle : Degradation of proteins depend on either ubiqutin or nonubiqutin cycle.in the cell cycle, the ubiqutin dependent protein degradation is important for the progression of cell cycle. It plays a impartant role for the regulation of cell cycle progression either. Dr.Tanaka (Tokushima U.) has identified proteins comprising the ubiqutin dependent proteasome and cloned the cDNA encoding these proteins.G protesin in the cell cycle : A small G protein functions as a biological switch. Thus far, many G proteins have been found to be involved in the signal transduction and the protein secretion. RCC1 which was cloned by the group of Dr.Nishimoto (Kyushu U.) functions as a GTP/GDP exchanging factor for a small nuclear GTPase Ran.Since loss of RCC1 induces premature initiation of mitosis, RCC1 is assumed to be involved in the cell cycle regulation Less

信号转导途径中的MAP激酶级联：MAP激酶已被鉴定为诱导磷酸化以激活由cdc 2和细胞周期蛋白B组成的成熟促进因子（MAF）的激酶。和Sakata（九州大学）阐明了Mos是MAP激酶级联反应中的关键调节因子。S期DNA复制许可因子的鉴定：在真核生物中，总基因组DNA在S期仅复制一次是非常重要的。为了做到这一点，人们假设细胞具有一个因子，只允许S期DNA复制的信号轮。在这项研究计划中，泷泽博士确定了允许单轮DNA复制的蛋白质因子。细胞周期中的细胞周期蛋白：细胞周期蛋白包括MPF或SPF以及cdc 2或cdks，它们被称为细胞周期引擎。在这种情况下，一个非常重要的问题是，为什么细胞周期蛋白对MPF是必不可少的， ...更多信息 SPF函数。小林博士（九州大学）和Kishimoto（Tokyou Engineering U.）细胞周期中的泛素系统：蛋白质的降解依赖于泛素或非泛素。cycle.in细胞周期中，泛素依赖的蛋白质降解对细胞周期的进展至关重要。它在细胞周期的调控中也起着重要的作用。田中博士（德岛大学）已经鉴定了组成泛素依赖性蛋白酶体的蛋白质，并克隆了编码这些蛋白质的cDNA。细胞周期中的G蛋白：一种小的G蛋白作为生物开关。迄今为止，已发现许多G蛋白参与信号转导和蛋白分泌。RCC 1是由Dr.Nishimoto（Kyushu U.）作为一个GTP/GDP的交换因子的一个小的核GTCRan的功能。由于RCC 1的损失诱导有丝分裂的过早启动，RCC 1被认为是参与细胞周期的调节减