Super-Biosystem Constructed by Cognitive Multidimensional Glyco-Molecules

认知多维糖分子构建的超级生物系统

• 批准号: 09240102
• 负责人: URYU Toshiyuki
• 金额: $ 24.58万
• 依托单位: Teikyo University of Science and Technology (1999-2000)The University of Tokyo (1997-1998)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09240102/
• 关键词: Saccharide chain synthesis; Aggregate of molecules; Control of biomolecules; Control of cell functions; Saccharide chain recognition; Glycopolymer; Functional polysaccharide; Biofunctional saccharide chain; 糖質自動合成システム; 共重合型糖鎖高分子; コレステロール置換プルラン /

(1) 7 simposiums had been held.(2) Research results of each investigator were concluded.(3) Research results of each group (A01 : basic research on superfine synthesis of saccharide chain ; A02 : aggregate of saccharide chain ; A03 : control of biomolecules by saccharide chain ; A04 : control of cell functions by cognitive multidimensional glyco-chain) were concluded.(4) Results of all the researchs includins cooperative researchs were concluded to produce a booklet written in English (316 pages).(5) Research results were published (946 original papers, 187 reviews, more than 1000 oral presentations, 121 books).(6) The book of "Design of Glyco-Molecules and Their Biological Functions" was edited.

（1）已举办7次研讨会。（2）总结各研究者的研究成果。（3）各组研究成果（A01：糖链超精细合成基础研究；A02：糖链聚集体；A03：糖链控制生物分子；A04：认知多维糖链控制细胞功能） （4）包括合作研究在内的所有研究成果总结成英文小册子（316页）。（5）发表研究成果（原创论文946篇，综述187篇，口头报告1000余篇，书籍121本）。（6）主编《糖分子及其生物学功能的设计》一书。

项目成果

K.-J.Jeon,K.Katsuraya,T.Inazu,Y.Kaneko,T.Mimura,and T.Uryu: "NMR Spectroscopic Detection of Interactions between a HIV Protein Sequence and a Highly Anti-HIV Active Curdlan Sulfate"J.Am.Chem.Soc.. 122. 12536-12541 (2000)

K.-J.Jeon、K.Katsuraya、T.Inazu、Y.Kaneko、T.Mimura 和 T.Uryu：“HIV 蛋白序列与高抗 HIV 活性凝胶多糖硫酸盐之间相互作用的核磁共振光谱检测”J

K.Kobayashi et al.: "Rigid Helical Poly(glycosyl phenyl isocyanide)s:Synthesis,Conformational Analysis,and Recognition by Lectins"Macromolecules. 32. 6595-6603 (1999)

K.Kobayashi 等人：“刚性螺旋聚（糖基苯基异氰化物）：合成、构象分析和凝集素识别”大分子。

K.Hatanaka et al.: "Chemical Synthesis of Comb-Shaped Polysaccharide Derivatives via Cationic Ring-Opening Polymerizarion and Copolymerization of an Anhydrodisaccharide Monomer"Macromolecules. 32. 2131-2136 (1999)

K.Hatanaka等人：“通过阳离子开环聚合和脱水二糖单体共聚化学合成梳形多糖衍生物”大分子。

K.Kobayashi, et al.: "A New Type of Artificial Glycocojugate Polymer:A Convenient Synthesis and Its Interaction with Lectins" Macromolecules. 30. 2016-2020 (1997)

K.Kobayashi 等人：“一种新型人工糖复合物聚合物：一种便捷的合成及其与凝集素的相互作用”大分子。

M.Kunou, K.Hatanaka et al.: "Synthesis of Sulfated Colominic Acid and Their Interaction with Fibroblast Growth Factors"Biomacromolecules. 1. 451-458 (2000)

M.Kunou、K.Hatanaka 等人：“硫酸化多聚氨基酸的合成及其与成纤维细胞生长因子的相互作用”生物大分子。