Role of amino acids in the central nervous system on the regulation of feeding behavior in chick

中枢神经系统氨基酸对雏鸡摄食行为调节的作用

• 批准号: 14560250
• 负责人: BUNGO Takashi
• 金额: $ 2.18万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14560250/
• 关键词: Feeding Behavior; Eating Disorders; Amino Acids; Metabolites; Central nervous system; Trophicity; Blood-brain barrier; ニワトリヒナ; 神経伝達物質; 神経調節物質; 中枢神経; ブロイラー; 産卵鶏

It is well known that food intake, as well as growth rate, is depressed by dietary ammo acid unbalances. One possible mechanism by which dietary amino acid composition pattern affects food intake is through the resulting changes in ammo acid profiles in the brain. However, there is little information for the mechanisms in chicks. The aim of the present study was investigated the effects of dietary amino acid unbalances, or intracerebroventricularly (ICV) injection of amino acids or metabolites on feeding behavior in chicks.Phenylalanine (Phe)-or tryptophan (Trp)-excess feed induced anorexia and ICV injection of Phe or Trp also decreased food intake in chicks. In contrast, feeding behavior in chicks was stimulated by central injection of methionine (Met) or leucine (Leu). It seemed that the central effect of Leu might contribute to metabolite, glutamate via glutaminergic system. In addition, pipecolic acid, the metabolite of lysine, might act on GABAergic system and suppressed food intake in chicks. On the other hand, there was possibility that Met perse might play a role as neuromodulator.Similar to mammals, it seemed that glutamate, GABA and glycine have an important role in the regulation of feeding behavior of chicks. However, it appeared that there was difference between layer and broiler chicks because the effects of GABA agents in layers were inconsistent in broilers. These results suggest that amino acids and/or these metabolites by which dietary amino acid composition pattern may influence feeding regulation via blood vessels in the central nervous system of chicks.

众所周知，食物摄入量以及生长速度受到膳食氨基酸不平衡的抑制。膳食氨基酸组成模式影响食物摄入的一个可能机制是通过大脑中氨基酸谱的变化。然而，关于雏鸡中的机制的信息很少。本研究旨在探讨饲粮氨基酸不平衡或侧脑室注射氨基酸或代谢产物对雏鸡摄食行为的影响，苯丙氨酸（Phe）或色氨酸（Trp）过量可引起雏鸡厌食，侧脑室注射Phe或Trp也可降低雏鸡摄食量。相反，中枢注射蛋氨酸（Met）或亮氨酸（Leu）可刺激雏鸡的摄食行为。提示Leu的中枢作用可能是通过多巴胺能系统产生代谢产物谷氨酸。赖氨酸的代谢产物哌啶酸可能作用于GABA能系统，抑制雏鸡摄食。与哺乳动物一样，谷氨酸、GABA和甘氨酸在鸡的摄食行为中也起着重要的调节作用。但由于GABA制剂在蛋鸡体内对肉鸡的影响不一致，因此在蛋鸡和肉鸡体内存在差异。这些结果表明，氨基酸和/或这些代谢产物的膳食氨基酸组成模式可能会影响通过血管在中枢神经系统的鸡的摄食调节。

项目成果

Izumi, T., Kawamura, K., Ueda, H., Bungo, T.: "Central administration of leucine, but not isoleucine and valine, stimulates feeding behavior in neonatal chicks."Neuroscience Letters. 354. 166-168 (2004)

Izumi, T.、Kawamura, K.、Ueda, H.、Bungo, T.：“集中施用亮氨酸，而不是异亮氨酸和缬氨酸，可以刺激新生雏鸡的摄食行为。”《神经科学快报》。

Takagi, T., Bungo, T., (他7名): "Intracerebroventricular administration of GABA-A and GABA-B receptor antagonists attenuate feeding and sleeping-like behavior induced by L-pipecolic acid in neonatal chicks."Journal of Neuroscience Research. 73. 270-275 (200

Takagi, T.、Bungo, T.（其他 7 人）：“脑室内给予 GABA-A 和 GABA-B 受体拮抗剂可减弱新生小鸡 L-哌可酸诱导的进食和睡眠样行为。”神经科学研究杂志73. 270-275 (200

Izumi, T., Kawamura K, Ueda J., Bungo, T.: "Central administration of leucine but not isoleucine and valine, stimulates feeding behavior in neonatal chicks."Neuroscience Letters. 354. 166-168 (2004)

Izumi, T.、Kawamura K、Ueda J.、Bungo, T.：“集中施用亮氨酸而非异亮氨酸和缬氨酸，可以刺激新生雏鸡的进食行为。”《神经科学快报》。

Izumi, T., Kawamura K., Ueda J., Bungo, T.: "Central administration of leucine but not isoleucine and valine, stimulates feeding behavior in neonatal chicks."Neuroscience Letters. 354. 166-168 (2004)

Izumi, T.、Kawamura K.、Ueda J.、Bungo, T.：“亮氨酸（而非异亮氨酸和缬氨酸）的中央给药可刺激新生雏鸡的摄食行为。”《神经科学快报》。

Bungo, T., Izumi, T., Kawamura, K., Takagi, T., Ueda, H., Furuse, M.: "Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake of layer-type, but not meat-type chicks."Brain Research. 993. 235-238 (2003)

Bungo, T.、Izumi, T.、Kawamura, K.、Takagi, T.、Ueda, H.、Furuse, M.：“脑室内注射蝇蕈醇、巴氯芬或哌啶酸会刺激蛋鸡的食物摄入，但不会刺激蛋鸡的食物摄入。”