MALARIA CONTROL STRATEGY AND BIODIVERSITIES OF HUMAN, PARASITES, MOSQUITOES AND ENVIRONMENT IN MELANESIA

美拉尼西亚的疟疾控制战略以及人类、寄生虫、蚊子和环境的生物多样性

基本信息

  • 批准号:
    14570224
  • 负责人:
  • 金额:
    $ 2.24万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2002
  • 资助国家:
    日本
  • 起止时间:
    2002 至 2003
  • 项目状态:
    已结题

项目摘要

We do the studies of malaria in isolated areas on Island Melanesia in comparison with Sub-Saharan Africa to investigate the interactions among diversities of humans, parasites, mosquitoes and environment to understand relations among transmission, immunity and disease.1.Our studies on merozoite surface protein-1 alleles of P.falciparum in Vanuatu suggested generally limited and stable genetic diversity on islands and a high degree of isolation between the islands, implying that malaria vaccines will be more effective where there is a limited gene pool, as in isolated populations.2.In the highland fringe of Western Kenya our survey showed that anemia was most common in children 【less than or equal】5 years of age (34%) followed by women of childbearing age (16%) in the lowland villages. In children 【less than or equal】5 years, both anemia (ranged from 57% at 1440m to 11% at 2040m) and P.falciparum (from 31% to 0%) prevalence significantly correlated with altitude, suggesting malaria is also the main cause of anemia in the highland fringe areas. Measures that reduce the prevalence of malaria will consequently reduce anemia and the need for blood transfusions associated with the risk of HIV transmission.3.On Aneityum island with low-to-moderate transmission, we have most probably interrupted transmission by combining MDA with impregnated bed nets and achieved sustained and significant gains (Kaneko 2000). The preliminary seroepidemiological results suggest that without antigenic stimulation immunologic memory will still remain for many years in adults previously repeatedly exposed to malaria.
我们在美拉尼西亚岛与撒哈拉以南非洲的隔离地区进行了疟疾研究,以调查人类,寄生虫,蚊子和环境之间的相互作用,以了解传播之间的关系,1.我们对裂殖子表面蛋白的研究-1等位基因表明,瓦努阿图的恶性疟原虫在岛屿上的遗传多样性总体上有限而稳定,岛屿之间的隔离程度较高,2.在肯尼亚西部的高原边缘地区,我们的调查显示贫血在低地村庄的5岁以下儿童(34%)中最为常见,其次是育龄妇女(16%)。在5岁以下儿童中,贫血(海拔1440 m时为57%~ 2040 m时为11%)和恶性疟原虫(海拔31%~ 0%)的患病率与海拔高度显著相关,提示疟疾也是高原边缘区贫血的主要原因。降低疟疾流行率的措施将减少贫血和与艾滋病毒传播风险相关的输血需求。3.在低至中度传播的Aneityum岛,我们很可能通过将MDA与浸渍蚊帐结合起来阻断了传播,并取得了持续和显著的成果(Kaneko 2000)。初步的血清流行病学结果表明,没有抗原刺激免疫记忆将仍然存在多年的成年人以前反复接触疟疾。

项目成果

期刊论文数量(104)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yusuf I, et al.: "Ethnic and geographical distributions of CYP2C19 alleles in the populations of Southeast Asia."Ady Exp Med Biol. 531. 37-46 (2003)
Yusuf I 等人:“东南亚人群中 CYP2C19 等位基因的种族和地理分布。”Ady Exp Med Biol。
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    0
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Tanabe K, et al.: "Stable SNPs in Malaria Antigen Genes in Isolated Populations."Science. 303(5657). 493 (2004)
Tanabe K 等人:“隔离人群中疟疾抗原基因中的稳定 SNP。”科学。
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    0
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Akhwale W, et al.: "Anemia and unstable malaria at different altitudes in the western highlands of Kenya."Acta Tro. (In press.).
Akhwale W 等人:“肯尼亚西部高地不同海拔地区的贫血和不稳定疟疾。”Acta Tro。
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    0
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Kaneko A.: "Methods in Malaria Research 4th ed, Ljunstrom, I.et al.(eds.)"Field blood sampling. In : Virginia : MR4/ATCC. 181-186 (2003)
Kaneko A.:“疟疾研究方法,第 4 版,Ljunstrom, I.et al.(eds.)”现场血液采样。
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    0
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Kilenga N, et al.: "Effect of wheat germ aggulutinin (WGA) binding to erythrocyte on Plasmodium falciparum invasion."Membrane. (In press).
Kilenga N 等人:“小麦胚芽凝集素 (WGA) 与红细胞结合对恶性疟原虫入侵的影响。”膜。
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    0
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KANEKO Akira其他文献

KANEKO Akira的其他文献

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{{ truncateString('KANEKO Akira', 18)}}的其他基金

Mass drug administration of Artemisinin and Ivermectin toward malaria elimination in tropical Africa
青蒿素和伊维菌素的大规模给药以消除热带非洲的疟疾
  • 批准号:
    18KK0248
  • 财政年份:
    2018
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
First malaria infection in infants on islands in Melanesia
美拉尼西亚岛屿上出现首例婴儿感染疟疾
  • 批准号:
    22406008
  • 财政年份:
    2010
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
The right to fair trial in criminal procedure
刑事诉讼中获得公平审判的权利
  • 批准号:
    22730053
  • 财政年份:
    2010
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
The Vocabulary Index of the Autograph by Japanese Buddhists in the Medieval Period as the Historical Studies of the Japanese Language
作为日语史研究的中世纪日本佛教徒亲笔词汇索引
  • 批准号:
    21520482
  • 财政年份:
    2009
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Study of partial differential equations and tomography by microlocal and discrete methods
通过微局部和离散方法研究偏微分方程和断层扫描
  • 批准号:
    20540157
  • 财政年份:
    2008
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Microlocal,FunctionalAnalytic and Numerical Study of Partial Differential Equations and Tomography
偏微分方程和层析成像的微局部、泛函分析和数值研究
  • 批准号:
    16540140
  • 财政年份:
    2004
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The descriptive research of the tradition and creation on the original letters in the three principal priests of Jhodo Shinshu descent
净土真宗三祖的原始字母传承与创作的描述性研究
  • 批准号:
    15520294
  • 财政年份:
    2003
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
HUMAN AND MALARIA PARASITE DIVERSITIES IN RELATION TO THE THERAPEUTIC EFFICACY OF ANTIMALARIALS ON ISLANDS IN THE ASIA AND PACIFIC
亚洲和太平洋岛屿上人类和疟疾寄生虫多样性与抗疟药疗效的关系
  • 批准号:
    13576030
  • 财政年份:
    2001
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Functional analytic and numerical study of partial differential equation and tomography
偏微分方程和断层扫描的泛函分析和数值研究
  • 批准号:
    12640158
  • 财政年份:
    2000
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Study on antimalarial efficacy and genetic diversities of human, parasites and mosquitoes
人类、寄生虫和蚊子的抗疟功效和遗传多样性研究
  • 批准号:
    11694318
  • 财政年份:
    1999
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B).
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