HUMAN AND MALARIA PARASITE DIVERSITIES IN RELATION TO THE THERAPEUTIC EFFICACY OF ANTIMALARIALS ON ISLANDS IN THE ASIA AND PACIFIC
亚洲和太平洋岛屿上人类和疟疾寄生虫多样性与抗疟药疗效的关系
基本信息
- 批准号:13576030
- 负责人:
- 金额:$ 8.58万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2001
- 资助国家:日本
- 起止时间:2001 至 2003
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We do the studies of malaria in isolated areas on Island Melanesia in comparison with Sub-Saharan Africa to investigate the interactions among diversities of humans, parasites, mosquitoes and environment to understand relations among transmission, immunity and disease.1.Our studies on merozoite surface protein-1 alleles of P.falciparum in Vanuatu suggested generally limited and stable genetic diversity on islands and a high degree of isolation between the islands, implying that malaria vaccines will be more effective where there is a limited gene pool, as in isolated populations.2.The East Sepik populations of PNG showed a moderate prevalence of CYP2C19-related poor metabolizer (PM), between Island Southeast Asia and Vanuatu, suggesting genetic drift is a main factor of the high prevalence of PM in the Pacific islands.3.In Malawi the switching from chloroquine (CHL) to sulfadoxine/pyrimethamine (SP) in 1993 resulted in a high prevalence rate (78%) of parasites with double dhps and triple dhfr (quintuple) mutations and a reduction in the prevalence of pfcrt K76T (2%) with the recovery of CHL efficacy in 2000. A haplotype analysis revealed that an expansion of wild pfcrt allele is the primary genetic mechanism for the recent recovery of the CHL sensitivity.4.In the highland fringe of Western Kenya our survey showed that anemia was most common in children 【less than or equal】5 years of age (34%) followed by women of childbearing age (16%) in the lowland villages. In children 【less than or equal】5 years, both anemia (ranged from 57% at 1440m to 11% at 2040m) and P.falciparum (from 31% to 0%) prevalence significantly correlated with altitude, suggesting malaria is also the main cause of anemia in the highland fringe areas. Measures that reduce the prevalence of malaria will consequently reduce anemia and the need for blood transfusions associated with the risk of HIV transmission.
我们将美拉尼西亚岛孤立地区的疟疾研究与撒哈拉以南非洲进行比较,以调查人类、寄生虫、蚊子和环境多样性之间的相互作用,以了解传播、免疫和疾病之间的关系。我们对瓦努阿图恶性疟原虫卵裂子表面蛋白-1等位基因的研究表明,岛屿上的遗传多样性一般有限而稳定,岛屿之间高度隔离,这意味着疟疾疫苗在基因库有限的地方更有效,如在孤立的种群中。巴布亚新几内亚东塞皮克人群在东南亚岛屿和瓦努阿图之间,cyp2c19相关的不良代谢物(PM)的患病率中等,表明遗传漂变是PM在太平洋岛屿高患病率的主要因素。在马拉维,1993年从氯喹(CHL)转向磺胺多辛/乙胺嘧啶(SP),导致双dhps和三dhfr(五倍)突变的寄生虫患病率很高(78%),2000年随着CHL疗效的恢复,pfcrt K76T的患病率降低(2%)。单倍型分析表明,野生pfcrt等位基因的扩增是最近CHL敏感性恢复的主要遗传机制。我们的调查显示,在肯尼亚西部的高地边缘地区,贫血在5岁以下儿童中最为常见(34%),其次是低地村庄的育龄妇女(16%)。在5岁以下儿童中,贫血(海拔1440米为57% ~海拔2040米为11%)和恶性疟原虫(海拔31% ~ 0%)患病率均与海拔高度显著相关,提示疟疾也是高原边缘地区贫血的主要原因。减少疟疾流行的措施将因此减少贫血和与艾滋病毒传播风险相关的输血需求。
项目成果
期刊论文数量(110)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Tanabe K, et al.: "Stable SNPs in Malaria Antigen Genes in Isolated Populations."Science. 303(5657). 493 (2004)
Tanabe K 等人:“隔离人群中疟疾抗原基因中的稳定 SNP。”科学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Kaneko A.: "Methods in Malaria Research 4th ed, Ljunstrom, I.et al.(eds.)"Field blood sampling. In : Virginia : MR4/ATCC. 181-186 (2003)
Kaneko A.:“疟疾研究方法,第 4 版,Ljunstrom, I.et al.(eds.)”现场血液采样。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Kilenga N, et al.: "Effect of wheat germ aggulutinin (WGA) binding to erythrocyte on Plasmodium falciparum invasion."Membrane. (In press).
Kilenga N 等人:“小麦胚芽凝集素 (WGA) 与红细胞结合对恶性疟原虫入侵的影响。”膜。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Sakihama N, et al.: "Limited recombination events in merozoite surface protein-1 alleles of Plasmodium falciparum on islands."Gene. 1279. 41-48 (2001)
Sakihama N 等人:“岛屿上恶性疟原虫裂殖子表面蛋白 1 等位基因中的有限重组事件。”基因。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
江藤秀顕 ら: "新版・感染症マニュアル,小早川隆敏編"東京:スパイラル出版. 972 (2002)
Hideaki Eto 等:“新版传染病手册,小早川隆俊编辑”东京:Spiral Publishing 972(2002)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
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KANEKO Akira其他文献
KANEKO Akira的其他文献
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{{ truncateString('KANEKO Akira', 18)}}的其他基金
Mass drug administration of Artemisinin and Ivermectin toward malaria elimination in tropical Africa
青蒿素和伊维菌素的大规模给药以消除热带非洲的疟疾
- 批准号:
18KK0248 - 财政年份:2018
- 资助金额:
$ 8.58万 - 项目类别:
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
First malaria infection in infants on islands in Melanesia
美拉尼西亚岛屿上出现首例婴儿感染疟疾
- 批准号:
22406008 - 财政年份:2010
- 资助金额:
$ 8.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
The right to fair trial in criminal procedure
刑事诉讼中获得公平审判的权利
- 批准号:
22730053 - 财政年份:2010
- 资助金额:
$ 8.58万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
The Vocabulary Index of the Autograph by Japanese Buddhists in the Medieval Period as the Historical Studies of the Japanese Language
作为日语史研究的中世纪日本佛教徒亲笔词汇索引
- 批准号:
21520482 - 财政年份:2009
- 资助金额:
$ 8.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study of partial differential equations and tomography by microlocal and discrete methods
通过微局部和离散方法研究偏微分方程和断层扫描
- 批准号:
20540157 - 财政年份:2008
- 资助金额:
$ 8.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Microlocal,FunctionalAnalytic and Numerical Study of Partial Differential Equations and Tomography
偏微分方程和层析成像的微局部、泛函分析和数值研究
- 批准号:
16540140 - 财政年份:2004
- 资助金额:
$ 8.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The descriptive research of the tradition and creation on the original letters in the three principal priests of Jhodo Shinshu descent
净土真宗三祖的原始字母传承与创作的描述性研究
- 批准号:
15520294 - 财政年份:2003
- 资助金额:
$ 8.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
MALARIA CONTROL STRATEGY AND BIODIVERSITIES OF HUMAN, PARASITES, MOSQUITOES AND ENVIRONMENT IN MELANESIA
美拉尼西亚的疟疾控制战略以及人类、寄生虫、蚊子和环境的生物多样性
- 批准号:
14570224 - 财政年份:2002
- 资助金额:
$ 8.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Functional analytic and numerical study of partial differential equation and tomography
偏微分方程和断层扫描的泛函分析和数值研究
- 批准号:
12640158 - 财政年份:2000
- 资助金额:
$ 8.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study on antimalarial efficacy and genetic diversities of human, parasites and mosquitoes
人类、寄生虫和蚊子的抗疟功效和遗传多样性研究
- 批准号:
11694318 - 财政年份:1999
- 资助金额:
$ 8.58万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
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