First malaria infection in infants on islands in Melanesia

美拉尼西亚岛屿上出现首例婴儿感染疟疾

基本信息

批准号：
22406008
负责人：
KANEKO Akira
金额：
$ 12.4万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010-04-01 至 2014-03-31
项目状态：
已结题

项目摘要

Aneityum, the southernmost island in Vanuatu, is located at the south-east edge of the malaria extension in the Pacific. To examine the feasibility of malaria elimination, an integrated program, combining mass drug administration (MDA) and vector control, was initiated on Aneityum in 1991. Microscopy showed Plasmodium falciparum immediately disappeared whereas P. vivax disappeared from 1996 onwards. Since 1991 community-based surveillance and vector control measures were continuously maintained. Eight years later, it was concluded that malaria can be eliminated from isolated islands if there is a high degree of community commitment. An epidemic of P. vivax on Aneityum in 2002 provided us with an opportunity to investigate resurgence. Adults born before elimination had considerably fewer episodes of parasitemia than children born after elimination, indicating that protective immunity against P. vivax infections persists for a long time after the initiation of malaria elimination.

Aneityum是瓦努阿图最南端的岛屿，位于太平洋疟疾延伸的东南边缘。为了检查消除疟疾的可行性，一项综合程序，结合了大规模药物给药（MDA）和载体控制，于1991年在Aneityum上启动。显微镜显示恶性疟原虫立即消失，而Vivax P. Vivax从1996年开始消失。自1991年以来，基于社区的监视和向量控制措施不断维护。八年后，得出结论，如果社区承诺高，可以从孤立的岛屿中消除疟疾。 2002年在苯甲酸疟原虫上的流行病为我们提供了调查复苏的机会。消除前出生的成年人的寄生虫病的发作比消除后出生的孩子少得多，这表明在消除疟疾消除疟疾后很长一段时间以来，针对疟原虫感染的保护性免疫持续存在。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax.

DOI：
10.1016/j.vaccine.2011.04.028
发表时间：
2011-06-10
期刊：
VACCINE
影响因子：
5.5
作者：
Doi, Masanori;Tanabe, Kazuyuki;Tachibana, Shin-Lchiro;Hamai, Meiko;Tachibana, Mayumi;Mita, Toshihiro;Yagi, Masanori;Zeyrek, Fadile Yildiz;Ferreira, Marcelo U.;Ohmae, Hiroshi;Kaneko, Akira;Randrianarivelojosia, Milijaona;Sattabongkot, Jetsumon;Cao, Ya-Ming;Horii, Toshihiro;Torii, Motomi;Tsuboi, Takafumi
通讯作者：
Tsuboi, Takafumi

Mass drug administration for malaria elimination on islands

大规模药物管理以消除岛屿上的疟疾

DOI：
发表时间：
2011
期刊：
影响因子：
0
作者：
Kaneko A
通讯作者：
Kaneko A

Characteristic Age Distribution of Plasmodium vivax Infections after Malaria Elimination on Aneityum Island, Vanuatu

DOI：
10.1128/iai.00931-13
发表时间：
2014-01-01
期刊：
INFECTION AND IMMUNITY
影响因子：
3.1
作者：
Kaneko, Akira;Chaves, Luis F.;Drakeley, Chris
通讯作者：
Drakeley, Chris

Plasmodium falciparum : a stowaway in our ancestors' journey out of Africa

恶性疟原虫：我们祖先离开非洲的旅程中的偷渡者

DOI：
发表时间：
2010
期刊：
Current Biol
影响因子：
0
作者：
Tanabe K;Mita T;Jombart T;Palacpac N;Ranford-Cartwright L;Sawai H;Sakihama N;Horibe S;Ohmae H;Nakamura M;Ferreira MU;Escalante AA;Bjorkman A;Farnert A;Kaneko A;Horii T;Kishino H;Balloux F
通讯作者：
Balloux F

Frequency of the Functionally Relevant Aryl Hydrocarbon Receptor Repressor (AhRR) Pro185Ala SNP in Papua New Guinea