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First malaria infection in infants on islands in Melanesia

美拉尼西亚岛屿上出现首例婴儿感染疟疾

基本信息

批准号：
22406008
负责人：
KANEKO Akira
金额：
$ 12.4万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2010
资助国家：
日本
起止时间：
2010-04-01 至 2014-03-31
项目状态：
已结题

项目摘要

Aneityum, the southernmost island in Vanuatu, is located at the south-east edge of the malaria extension in the Pacific. To examine the feasibility of malaria elimination, an integrated program, combining mass drug administration (MDA) and vector control, was initiated on Aneityum in 1991. Microscopy showed Plasmodium falciparum immediately disappeared whereas P. vivax disappeared from 1996 onwards. Since 1991 community-based surveillance and vector control measures were continuously maintained. Eight years later, it was concluded that malaria can be eliminated from isolated islands if there is a high degree of community commitment. An epidemic of P. vivax on Aneityum in 2002 provided us with an opportunity to investigate resurgence. Adults born before elimination had considerably fewer episodes of parasitemia than children born after elimination, indicating that protective immunity against P. vivax infections persists for a long time after the initiation of malaria elimination.

瓦努阿图最南端的岛屿Aneityum位于太平洋疟疾蔓延区的东南边缘。为了研究消灭疟疾的可行性，1991年在阿内蒂乌姆启动了一项综合方案，将大规模药物管理（MDA）和病媒控制相结合。显微镜检查显示恶性疟原虫立即消失，而间日疟原虫从1996年起消失。自1991年以来，继续保持以社区为基础的监测和病媒控制措施。八年后得出的结论是，如果社区作出高度承诺，疟疾是可以在孤岛上消除的。2002年间日疟原虫在Aneityum上的流行为我们提供了一个研究其死灰复燃的机会。在消灭疟疾之前出生的成年人比消灭疟疾之后出生的儿童的寄生虫血症发作次数少得多，这表明对间日疟原虫感染的保护性免疫在消灭疟疾开始后持续很长一段时间。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Plasmodium falciparum : a stowaway in our ancestors' journey out of Africa

恶性疟原虫：我们祖先离开非洲的旅程中的偷渡者

DOI：
发表时间：
2010
期刊：
Current Biol
影响因子：
0
作者：
Tanabe K;Mita T;Jombart T;Palacpac N;Ranford-Cartwright L;Sawai H;Sakihama N;Horibe S;Ohmae H;Nakamura M;Ferreira MU;Escalante AA;Bjorkman A;Farnert A;Kaneko A;Horii T;Kishino H;Balloux F
通讯作者：
Balloux F

Characteristic Age Distribution of Plasmodium vivax Infections after Malaria Elimination on Aneityum Island, Vanuatu

DOI：
10.1128/iai.00931-13
发表时间：
2014-01-01
期刊：
INFECTION AND IMMUNITY
影响因子：
3.1
作者：
Kaneko, Akira;Chaves, Luis F.;Drakeley, Chris
通讯作者：
Drakeley, Chris

Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax.

DOI：
10.1016/j.vaccine.2011.04.028
发表时间：
2011-06-10
期刊：
VACCINE
影响因子：
5.5
作者：
Doi, Masanori;Tanabe, Kazuyuki;Tachibana, Shin-Lchiro;Hamai, Meiko;Tachibana, Mayumi;Mita, Toshihiro;Yagi, Masanori;Zeyrek, Fadile Yildiz;Ferreira, Marcelo U.;Ohmae, Hiroshi;Kaneko, Akira;Randrianarivelojosia, Milijaona;Sattabongkot, Jetsumon;Cao, Ya-Ming;Horii, Toshihiro;Torii, Motomi;Tsuboi, Takafumi
通讯作者：
Tsuboi, Takafumi

Mass drug administration for malaria elimination on islands

大规模药物管理以消除岛屿上的疟疾