Comparison of sensitivities for colorectal cancer between the guaian-based fecal occult blood test (FOBT) and an immunochemical FOBT.

本研究比较免疫化学粪便潜血试验(IFOBT)和愈创木酚粪便潜血试验(FOBT)的敏感性。受试者是2858名在多相健康检查中接受结肠镜检查的人，以及523名没有大便出血的门诊患者，他们因腹部症状在胃肠道单元接受结肠镜检查。IFBT检测151例阳性，FOBT检测338例阳性。在16例结直肠癌患者中，IFOBT阳性10例，愈创木酚FOBT阳性5例。iFOBT和FOBT的敏感度分别为63%和31%。两种试验之间的敏感性没有统计学上的显着差异(p=0.08)，这可能是因为样本量较小，首次筛查的比例(约10%)低于研究开始时的预期。有人建议iFOBT比FOBT具有更高的灵敏度，然而，需要更大的样本量才能获得显著的结果。

This study was conducted to compare sensitivity of immunochemical fecal occult blood test(IFOBT) with that of guaiac FOBT. Subjects were 2858 individuals who underwent colonoscopy as part of a multiphasic health examination and 523 outpatients without bloody stool who underwent colonoscopy at a gastrointestinal unit because of abdominal symptoms. Positive results were obtained in 151 and 338 subjects with IFOBT and FOBT, respectively. Cancer was found in 10 individuals and 6 outpatients.IFOBT gave positive results in 10 out of 16 patients with colorectal cancer, while guaiac FOBT did 5 out of 16. Sensitivities were calculated to be 63% and 31% for IFOBT and FOBT, respectively. There was no statistically significant difference in sensitivity between the two tests (p=0.08) probably due to a smaller sample size and a lower proportion of first-time screenees (approximately 10%) than those expected at the beginning of this study. IFOBT was suggested to be higher in sensitivities than FOBT, however, a larger sample size will be needed to obtain significant results showing it.