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Molecular epidemiological intervention study for life-related disease using behavior science and sib-pair analysis

利用行为科学和同胞对分析进行生命相关疾病的分子流行病学干预研究

基本信息

批准号：
14570332
负责人：
SAKANE Naoki
金额：
$ 2.56万
依托单位：
National Hospital Organization Kyoto Medical Center (Clinical Research Institute) (2004-2005)Kobe University (2002-2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570332/
关键词：
Life-related disease Molecular Epidemioology Behavioral science

项目摘要

To prevent the metabolic syndrome, 114 abdominal obesity subjects were screened from 315 subjects in health check up systems. After 3-month's lifestyle intervention based on the behavioral science in 20 abdominal obesity subjects, body weight and serum triglyceride levels were significantly decreased (-3.8kg and -24mg/dl, respectively). After lifestyle intervention, the prevalence of metabolic syndrome was reduced by half. Hyperlipidemic subjects with the Trp64Arg polymorphism in the β3-adrenergic receptor gene, which were associated with decreased resting metabolic rate and lipolysis in white adipose tissue, had difficulties to reduce body weight and serum total cholesterol levels compared with those without the Trp64Arg polymorphism. Hyperlipidemic subjects with the promoter region polymorphism (-3826A/G) in the uncoupling protein 1 gene, which was associated with reduced thermogensis after loading high-gat diets, also had difficulties to reduce body weight and serum total cholestero … More l levels compared with those without this polymorphism. Hyperlipidemic subjects with the D allele in the ACE gene had difficulties to reduce body weight compared those without the D allele, although there was no difference in serum total cholesterol between subjects with or without the D allele. Inversely, hyperlipidemic subjects with Thr54 allele in the fatty acid binding protein 2 gene had difficulties to reduce cholesterol levels compared with the allele, although there was no difference in changes of body weight between subjects with or without the Thr54 allele. To investigate the effects of heredity on body mass index (BMI) and threshold level for salt taste in 41 families. The BMI and serum total cholesterol levels in children was positively correlated with those in the mother, but not significantly associated with those of the father. BMI in children was associated with skipping breakfast and walking hours. Thus, rational and individually tailored therapies may be developed to combat obesity and its associated disorders. Less

为了预防代谢综合征，从健康体检系统的315名受试者中筛选出114名腹部肥胖受试者。20例腹型肥胖患者在行为科学生活方式干预3个月后，体重和血清甘油三酯水平均显著降低（分别为-3.8kg和-24mg/dl）。生活方式干预后，代谢综合征的患病率降低了一半。β3-肾上腺素能受体基因Trp64Arg多态性与白色脂肪组织静息代谢率和脂肪分解降低相关的高脂血症受试者，与没有Trp64Arg多态性的受试者相比，难以降低体重和血清总胆固醇水平。具有解偶联蛋白1基因启动子区多态性（-3826A/G）的高脂血症受试者在高负荷饮食后与生热作用降低有关，也难以降低体重和血清总胆固醇。在ACE基因中有D等位基因的高脂血症受试者与没有D等位基因的受试者相比，很难减轻体重，尽管在有或没有D等位基因的受试者之间血清总胆固醇没有差异。相反，在脂肪酸结合蛋白2基因中携带Thr54等位基因的高脂血症患者与该等位基因相比，降低胆固醇水平的难度更大，尽管携带或不携带Thr54等位基因的受试者体重变化没有差异。目的探讨遗传对41个家庭的体质指数（BMI）和盐味阈值的影响。儿童的BMI和血清总胆固醇水平与母亲的BMI和血清总胆固醇水平呈正相关，但与父亲的BMI和血清总胆固醇水平无显著相关。儿童的身体质量指数与不吃早餐和步行时间有关。因此，合理和个性化的治疗方法可能会被开发出来，以对抗肥胖及其相关疾病。少