Community-based molecular preventive study on diabetic nephropathy

基于社区的糖尿病肾病分子预防研究

• 批准号: 19590617
• 负责人: SAKANE Naoki
• 金额: $ 2.91万
• 依托单位: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590617/
• 关键词: 糖尿病; 腎症; 慢性腎臓病; 遺伝子多型; 介入; 時計遺伝子; 食事療法; 微量アルブミン尿; 分子疫学; 予防医学; アディポネクチン; 脂質; イソフラボン; エクオール; アンジオテンシン変換酵素; 肥満

The prevalence of chronic kidney disease (CKD) was 26.9% in the model community and higher than average (18.7%) for Japanese. The body mass index was associated with estimated GFR independent of age, gender, and ACE polymorphism. Several polymorphisms such as beta3-aderenoceptor were associated with the production of small dense LDL, which shows a high prevalence in diabetic nephropathy. A dietary salt reduction program using family and community support significantly decreased the blood pressure and urine albuminurea. These findings suggest that the early detection and prevention of diabetic nephropathy is important.

慢性肾脏病（CKD）的患病率为26.9%，高于日本的平均水平（18.7%）。体重指数与估计的GFR相关，与年龄、性别和ACE多态性无关。一些多态性如β 3-肾上腺素能受体与小而密LDL的产生有关，这表明糖尿病肾病的发病率很高。通过家庭和社区支持的饮食减盐计划显著降低了血压和尿白蛋白尿素。这些发现表明，早期发现和预防糖尿病肾病是重要的。

项目成果

The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with increased small dense low-density lipoprotein in a rural Japanese population: the Mima study.

• DOI: 10.1016/j.metabol.2007.07.012
• 发表时间: 2007-12
• 期刊: Metabolism: clinical and experimental
• 作者: K. Tsuzaki;K. Kotani;Shinji Fujiwara;Y. Sano;Yukiyo Matsuoka;Masayuki Domichi;T. Hamada;A. Shimatsu;N. Sakane

Clustered components of the m, etabolic syndrome and platelet counts Japanese females.

日本女性 m 的聚集成分、代谢综合征和血小板计数。

• 发表时间: 2007
• 期刊: Clin Chem Lab Med 45
• 作者: Kondo T;Kimata A;Yamamoto K;Ueyama S;Ueyama J;Hori Y.;Kotani K
• 通讯作者: Kotani K

Serum adiponectin levels and lifestyle factors in Japanese men

• DOI: 10.1007/s00380-006-0969-2
• 发表时间: 2007-09-01
• 期刊: HEART AND VESSELS
• 影响因子: 1.5
• 作者: Kotani, Kazuhiko;Sakane, Naoki;Kurozawa, Yosuke Kato Youichi
• 通讯作者: Kurozawa, Yosuke Kato Youichi

The association of the Clock 3111 T/C SNP with lipids and lipoproteins including small dense low-density lipoprotein: results from the Mima study.

• DOI: 10.1186/1471-2350-11-150
• 发表时间: 2010-10-21
• 期刊: BMC medical genetics
• 作者: Tsuzaki K;Kotani K;Sano Y;Fujiwara S;Takahashi K;Sakane N
• 通讯作者: Sakane N

Adiponectin and lipoprotein particle size

脂联素和脂蛋白粒径

• 发表时间: 2010
• 期刊: Diabetes Care 2010 33巻
• 作者: Tsuzaki K;Kotani K;Fujiwara S;Sakane N.
• 通讯作者: Sakane N.