Community-based molecular preventive study on diabetic nephropathy

慢性肾脏病（CKD）的患病率为26.9%，高于日本的平均水平（18.7%）。体重指数与估计的GFR相关，与年龄、性别和ACE多态性无关。一些多态性如β 3-肾上腺素能受体与小而密LDL的产生有关，这表明糖尿病肾病的发病率很高。通过家庭和社区支持的饮食减盐计划显著降低了血压和尿白蛋白尿素。这些发现表明，早期发现和预防糖尿病肾病是重要的。

The prevalence of chronic kidney disease (CKD) was 26.9% in the model community and higher than average (18.7%) for Japanese. The body mass index was associated with estimated GFR independent of age, gender, and ACE polymorphism. Several polymorphisms such as beta3-aderenoceptor were associated with the production of small dense LDL, which shows a high prevalence in diabetic nephropathy. A dietary salt reduction program using family and community support significantly decreased the blood pressure and urine albuminurea. These findings suggest that the early detection and prevention of diabetic nephropathy is important.