Community-based molecular preventive study on diabetic nephropathy

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The prevalence of chronic kidney disease (CKD) was 26.9% in the model community and higher than average (18.7%) for Japanese. The body mass index was associated with estimated GFR independent of age, gender, and ACE polymorphism. Several polymorphisms such as beta3-aderenoceptor were associated with the production of small dense LDL, which shows a high prevalence in diabetic nephropathy. A dietary salt reduction program using family and community support significantly decreased the blood pressure and urine albuminurea. These findings suggest that the early detection and prevention of diabetic nephropathy is important.