Evaluation of effect of response shift for QOL measurement

评估反应转变对 QOL 测量的影响

• 批准号: 14570358
• 负责人: YAMAOKA Kazue
• 金额: $ 1.86万
• 依托单位: The National Institute of Public Health (2003)Teikyo University (2002)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570358/
• 关键词: health-related QOL; outcome index; Response shift; longitudinal data; cancer patients; evaluation; measurement; development; アウトカム指数

Recently, patient-reported health-related quality of life (HRQOL) has received increased attention as an outcome measure in cancer clinical trials, beyond the traditional biomedical markers of the disease. 'Response shift' was defined as changes in the meaning of one's self-evaluation of QOL resulting from changes in internal standards, values, or conceptualization, and was indicated by Allinson (1997) and Schwarts (1999). Integrating response shift into QOL research would allow a better understanding of how QOL is affected by changes in health status and would direct the development of reliable and valid measures for assessing changes in QOL.The objective of this study was to investigate whether response shift in the measurement of generic QOL occurred in persons with lung cancer patients. In particular, the impact of the response-shift phenomenon and related factors were examined using longitudinal data.The subjects were lung cancer inpatients. HRQOL20 (Yamaoka et al.,1994) and EORTC QLQ-C30 were used as outcome indices. The relations between QOL scores and medical treatment were examined by adjusting Performance Score and Eysenck Personality Questionnaire (Eysenck, HJ 1987,Shigehisa, et al. 1987) as well as gender and age.

最近，患者报告的健康相关生活质量（HRQOL）作为癌症临床试验中的结果指标越来越受到关注，超越了疾病的传统生物医学标志物。Allinson（1997）和Schwarts（1999）将“反应转移”定义为由于内部标准、价值观或概念化的变化而导致的自我生活质量评价意义的变化。将反应转移整合到生活质量研究中可以更好地了解生活质量如何受到健康状况变化的影响，并指导发展可靠和有效的措施来评估生活质量的变化。本研究的目的是调查肺癌患者的一般生活质量测量是否发生反应转移。特别地，使用纵向数据来检验反应偏移现象和相关因素的影响。HRQOL 20（Yamaoka等人，1994）和EORTC QLQ-C30作为结局指标。通过调整行为评分和艾森克个性问卷（Eysenck，HJ 1987，Shigehisa，et al. 1987）以及性别和年龄来检验QOL评分与药物治疗的关系。

项目成果

Watanabe, M, Yamaoka K, Yokotsuka M, Tango T.: "Randomized controlled trial of a new dietary education program to prevent type 2 diabetes in a high-risk group of Japanese male workers"Diabetes Care. 26. 3209-3214 (2003)

Watanabe, M, Yamaoka K, Yokotsuka M, Tango T.：“针对日本男性工人高危人群预防 2 型糖尿病的新饮食教育计划的随机对照试验”糖尿病护理。

Nomura K, Yamaoka K, Okano K, Yano E: "Investigating an effect of individual risk perception on attitude towards volcano observatory, how do we approach the volcanic gas disaster?"Journal of Human and Ecological Risk Assessment. (in press).

Nomura K、Yamaoka K、Okano K、Yano E：“调查个人风险认知对火山观测站态度的影响，我们如何应对火山气体灾难？”《人类与生态风险评估杂志》。

Nomura K, Yamaoka K, Okano K, Yano E: "Investigating an effect of individual risk perception on attitude towards volcano observatory, how do we approach the volcanic gas disaster?"Journal of Human and Ecological Risk Assessment. (In press). (2004)

Nomura K、Yamaoka K、Okano K、Yano E：“调查个人风险认知对火山观测站态度的影响，我们如何应对火山气体灾难？”《人类与生态风险评估杂志》。

Yamaoka K, Takeda Y.: "Analysis of the structure of HRQOL2O and measurement scale."Annual meeting of statistical federal association, Se 2002 (Tokyo).

Yamaoka K，Takeda Y.：“HRQOL2O 结构和测量量表分析。”统计联邦协会年会，Se 2002（东京）。

Yamaoka K, Takeda Y, Shigehisa T, Ogoshi K, Kobayashi K, Hayashi F, Hayashi C.: "Health-related quality of life in Japanese lung cancer patients as determined by two questionnaires : the HRQOL-20 and the EORTC QLQ-C30"Annals of Cancer Research and Therapy

Yamaoka K、Takeda Y、Shigehisa T、Ogoshi K、Kobayashi K、Hayashi F、Hayashi C.：“日本肺癌患者的健康相关生活质量由两份问卷确定：HRQOL-20 和 EORTC QLQ-C30