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Outcome evaluation in health science : Cross-cultural equivalence in the quality of life scoring procedure

健康科学的结果评估：生活质量评分程序的跨文化等效性

基本信息

批准号：
17590567
负责人：
YAMAOKA Kazue
金额：
$ 2.24万
依托单位：
The National Institute of Public Health
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590567/
关键词：
QOL Scoring method equivalence multicultural evaluation EORTC QLQ-C30 HRQOL20 applicability アウトカム指標文化差

项目摘要

In the field of health science, assessment of Health related Quality of Life (QOL) has been important and international comparison becoming critical issue. It is essential to conduct international bridging studies to clarify cross-cultural validity of QOL scales, evaluating each scale item equally in divergent contexts of cultures, demonstrating appropriate item-response correlations and construct validity of the scales.The aim of the study was to establish a standardized, cross-culturally equivalent, evaluation procedure for QOL assessment as an outcome measure in cancer clinical trials. For this major goal, the study aimed at to examine QOL scores and scoring methods of the questionnaires using the data from the Netherlands and Japan.First, a comparison of the scores and scoring methods of the EORTC QLQ-C30 and HRQOL-20 was conducted. Subjects were cancer patients (lung, breast, digestive, and prostate cancer) in the Netherlands and Japan. The data were summarized using summary statistics. The structures of the questionnaires were examined using factor analysis and correspondence analysis. The factors analyzed by factor analysis (PROMAX solution) were somewhat different from each other in the both countries. However, the results suggest that total score (QL2) as well as main subscales could be useful for cross-cultural comparison of the two countries.Second, in order to establish a standardized evaluation procedure for QOL assessment as an outcome measure in cancer clinical trials, cross-cultural validity between two different cultures in the QOL scoring procedure is examined for the patients in the Netherlands and Japan. The subjects were restricted to breast and lung cancer patients. The basic statistics were summarized. The detailed analysis will be subsequently conducted.

在健康科学领域，健康相关生活质量（QOL）的评价已成为一个重要的研究课题，国际间的比较也成为一个重要的研究课题。进行国际桥接研究以澄清QOL量表的跨文化效度，在不同的文化背景下平等地评估每个量表项目，证明适当的项目反应相关性和量表的结构效度是至关重要的，本研究的目的是建立一个标准化的，跨文化等效的，评价程序的QOL评估作为癌症临床试验的结果测量。为了达到这一目的，本研究采用了来自荷兰和日本的数据，首先对EORTC QLQ-C30和HRQOL-20的得分和评分方法进行了比较。受试者为荷兰和日本的癌症患者（肺癌、乳腺癌、消化道癌和前列腺癌）。使用汇总统计量总结数据。问卷的结构采用因子分析和对应分析进行检验。因子分析（PROMAX解决方案）分析的因素在两国有所不同。然而，研究结果表明，总评分（QL 2）以及主要分量表可以用于两国的跨文化比较。第二，为了建立一个标准化的评价程序的QOL评估作为一个结果的措施，在癌症临床试验，跨文化效度两种不同的文化之间的QOL评分程序在荷兰和日本的患者进行了检查。受试者仅限于乳腺癌和肺癌患者。总结了基本统计数据。随后将进行详细分析。