权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

MRI-ASL perfusion imaging -evaluation in pediatric brain and moyamoya disease-

MRI-ASL 灌注成像 - 儿科脑部和烟雾病的评估 -

基本信息

批准号：
14570833
负责人：
TAKAHASHI Shoki
金额：
$ 2.56万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

1.Cerebral blood flow in MRI-ASL (FAIR) perfusion imaging2.SPIO Brain Perfusion Imaging : Intraindividually Controlled Randomized Crossover Comparison Study of SPIO versus GdOur results showed a clinical equivalence of perfusion imaging using SPIO and Gd.3.MRI-ASL (FAIR) perfusion imaging : Intraindividually Controlled Randomized Crossover Comparison Study of FAIR versus Gd perfusionOur results indicate that good contrast between the cortex and white matter in both FAIR and Gd perfusion. Good positive relation ship was seen between in FAIR and in the relative blood flow or blood volume in Gd perfusion (r = 0.78 and 0.448, respectively).4.MRI-ASL (FAIR) perfusion imaging in the developing brainRegional pattern of the cerebral bloofd flow derived from FAIR was similar to the PET data reported in the previous literatures, however low signal to noise ratio in FAIR image paused a problem.5.Posterior Circulation and Ischemic Stroke in Pediatric Moyamoya DiseaseOur results indicate that reduced leptomeningeal collaterals from affected posterior cerebral artery are closely related to completed strokes rather than transient ischmic attask and transdural collaterals may not be sufficient to compensate for reduced leptomeningeal collaterals. The early involvement of posterior cerebral artery in hemispheres with the less advanced internal carotid artery lesions might be resposnsible for the high prevalence of completed strokes in young children.

1. MRI-ASL（FAIR）灌注成像中的脑血流2.SPIO脑灌注成像：SPIO与Gd的个体内对照随机交叉比较研究我们的结果显示使用SPIO和Gd的灌注成像的临床等效性。3.MRI-ASL（FAIR）灌注成像：FAIR与Gd灌注的个体对照、随机交叉对比研究结果表明，在脑皮质和白色物质之间，在FAIR和Gd灌注中。FAIR与Gd灌注时的相对血流量或血容量呈良好的正相关（r分别为0.78和0.448）.4.发育期脑的MRI-ASL（FAIR）灌注成像由FAIR获得的脑血流的区域模式与以往文献报道的PET数据相似，然而，FAIR图像低信噪比使问题暂停。5.儿童Moyamoya病的后循环和缺血性卒中我们的研究结果表明，受影响的大脑后动脉的软脑膜侧支减少与完全性卒中密切相关，而不是短暂性缺血发作和经硬膜侧支可能不足以补偿减少的软脑膜侧支。颈内动脉病变程度较轻的大脑半球的大脑后动脉早期受累可能是幼儿完全性卒中发病率高的原因。