Hypoxic brain damage : MR imaging findings and its correlation with histological findings

缺氧性脑损伤：磁共振成像结果及其与组织学结果的相关性

基本信息

批准号：
06670897
负责人：
TAKAHASHI Shoki
金额：
$ 1.28万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

We investigated sequential MR imaging findings of hypoxic encephalopathy and correlated them with histological findings at autopsy. We retrospectively reviewed sequential MR imaging studies of the brain in 6 patients with hypoxic brain damage. Sequential changes in signal intensity and morphological features of the brain were evaluated on repeated MR images. In the other two autopsied patientnts who had MR findings suggestive of cortical laminar necrosis, MR findings were correlated with histological findings. MR imaging was performed with a 1.5-T Magnetom H15 scanner (Siemens, Erlangen, Germany) with a head coil. T1-weighted spin-echo images, with a pulse sequence of 500/15 (repetition time [TR] msec/echo time msec) and long TR spin-echo (2500/15,90) images were obtained in the axial plane, with a 256^<**>256 matrix, a 5-10-mm section thickness, and a field of view of 20-25 cm. Occasionally, additional coronal or sagittal images were obtined. Temporal evolution of MR imaging findings … More was arbitrarily divided into frou morphological stages : acute stage, within 1 week after the onset ; early subacute stage, days 11-19 ; late subacute stage, days 21-28 ; and chronic stage, days 41 onward.Involvement of the watershed zones in the parietooccipitotemporal cortex was most frequent. Cerebral edema was seen in the acute stage. Enhanced T1-weighted images showed cortical laminar enhancement in the early subacute stage ; unenhanced T1-weighted images revealed characteristic laminar hyperintense lesions in the late subacute stage. Both of these findings reflected cortical laminar necrosis at histology. However, we could not elucidate at histological examination what caused the laminar hyperintensity on T1-weighted images. In the chronic stage, cortical atrophy and delayd but progressive white matter changes were seen. Changes in MR imaging features of hypoxic brain damage are complex but distinct. Cortical laminar necrosis and delayd white matter degeneration can be delineated. Less

我们研究了缺氧性脑病的顺序MR成像发现，并将其与尸检时的组织学发现相关。我们回顾性地回顾了6例低氧脑损伤患者中大脑的顺序MR成像研究。在重复的MR图像上评估了大脑信号强度和形态特征的顺序变化。在其他有MR结果的尸检患者中，提示皮质层状坏死的患者，MR发现与组织学发现相关。 MR成像是用1.5-T磁磁H15扫描仪（西门子，德国Erlangen，德国）进行的。 T1加权自旋回波图像，脉冲序列为500/15（重复时间[TR] MSEC/ECHO TIME MSEC）和长TR Spin-Echo（2500/15,90）图像，在轴向平面上获得，具有256^<**> 256> 256个Matrix，5-10毫米的厚度厚度为20-25 cm ave of Vise of Viefs of afthemant平面，并具有256^<**> 256个Matrix，一个5-10毫米的截面。有时，观察到其他冠状图像。 MR成像发现的时间演变……更多地分为形态学阶段：急性阶段，在发作后的1周内；早期亚急性阶段，第11-19天；亚急性晚期，第21-28天；和慢性阶段，第41天开始。副型皮层中的流域区域最频繁。在急性阶段看到脑水肿。增强的T1加权图像显示了早期亚急性阶段的皮质层状增强。未增强的T1加权图像显示在后期阶段晚期显示出特征性的层状高强度病变。这两个发现反映了组织学上皮质层状坏死。但是，我们无法在组织学检查中阐明是什么引起T1加权图像上层层高强度的原因。在慢性阶段，可以看到皮质萎缩和延迟但进行性的白质变化。低氧脑损伤的MR成像特征的变化很复杂，但截然不同。可以划定皮质层状坏死和延迟的白质变性。较少的