Usefulness of the 3 tesla MRI in the differential diagnosis between recurrence of glioma and non-tumoral treatment related changes including radiation necrosis.

3 特斯拉 MRI 在神经胶质瘤复发和非肿瘤治疗相关变化（包括放射性坏死）之间的鉴别诊断中的作用。

• 批准号: 23591746
• 负责人: TAKAHASHI Shoki
• 金额: $ 2.41万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591746/
• 关键词: グリオーマ; 脳腫瘍; 放射線壊死; MRI; 灌流画像; 拡散強調画像; 潅流画像; MRスペクトロスコピー; 磁化率強調画像

We determined whether 3 tesla MRI is useful in distinguishing recurrence of glioma from post-treatment changes including radiation necrosis. MRI sequences in this study included contrast-enhanced perfusion weighted imaging (PWI), apparent diffusion coefficient (ADC), susceptibility weighted images (SWI) and MR spectroscopy (MRS). PWI with double-dosed contrast agent was robust sequence for evaluation of CBV and is useful for discrimination between recurrence of gliomas and post-treatment changes. However, bevacizumab, a newly introduced drug which reduces tumor neoangiogenesis, may underestimate CBV, leading to misdiagnose viable tumor as treatment related change. Further evaluation is needed for PWI under administration of bevacizumab. As for ADC, one of the hopeful sequences, recurrence of gliomas had a propensity to show lower ADC value than treatment related changes. SWI and MRS revealed considerable overlaps between two entities. Future quantitative analysis may be promising.

我们确定 3 特斯拉 MRI 是否有助于区分神经胶质瘤的复发和治疗后的变化（包括放射性坏死）。本研究中的 MRI 序列包括对比增强灌注加权成像 (PWI)、表观扩散系数 (ADC)、磁敏感加权图像 (SWI) 和磁共振波谱 (MRS)。使用双剂量造影剂的 PWI 是评估 CBV 的可靠序列，并且有助于区分神经胶质瘤复发和治疗后变化。然而，贝伐珠单抗（一种新推出的减少肿瘤新生血管生成的药物）可能会低估 CBV，导致将活肿瘤误诊为治疗相关的变化。需要对贝伐珠单抗给药下的 PWI 进行进一步评估。至于 ADC（有希望的序列之一），神经胶质瘤的复发倾向于显示比治疗相关变化更低的 ADC 值。 SWI 和 MRS 显示两个实体之间存在相当大的重叠。未来的定量分析可能很有希望。