Development of new screening digital chest radiography with respiratory kinetic analysis

我们正在开发一种动态筛查x线摄影技术，利用平板探测器（FPD）系统提供肺呼吸的动力学信息。我们修改了FPD系统（CANON CXDI-22），以拍摄短时间（10秒，3帧/秒）的连续图像。从完全吸气到呼气连续拍摄胸片，分析膈肌运动及局部肺区密度变化，客观发现呼吸异常。我们的分析方法用于6名健康志愿者和1名肺气肿患者。该方法导出了局部空气通度和肺结构运动等呼吸功能，提示可以定量评价慢性阻塞性肺疾病和间质性肺炎的程度。该结果代表了一种可能构成诊断某些肺部疾病（如慢性阻塞性肺病、纤维瘤肺和肺炎）的新方法的发展的初始阶段。目前正在对我们的方法进行临床评估。

We are developing a dynamic screening radiography, which provide the kinetic information for lung respiratory using flat-panel detector (FPD) system.We modified the FPD system (CANON CXDI-22) to take the sequential images for a short time (10 seconds, 3 frames/sec). The sequential chest radiographs from full inspiration to expiration were taken and analyzed the diaphragm movements and the density changes at local lung area to detect respiratory anomalies objectively.Our method of analysis was used for six healthy volunteers and one emphysema patient. This method derived some respiratory functions such as regional air pass and lung structure movement, and suggested that degree of chronic obstructive pulmonary diseases and interstitial pneumonia could be evaluated quantitatively. The results represent the initial stage in the development of a method that may constitute a new method for diagnosing certain pulmonary diseases, such as chronic obstructive pulmonary disease, fibroid lung, and pneumonia. A clinical evaluation of our method is now in progress.