Evaluation of functional tumor blood flow map using dynamic MRI and compartment analysis

使用动态 MRI 和室分析评估功能性肿瘤血流图

• 批准号: 14570864
• 负责人: SUGAWARA Yoshifumi
• 金额: $ 1.15万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570864/
• 关键词: tumor; blood flow; angiogenesis; MRI; gadolinium; compartment analysis; deconvolution analysis

Angiogenesis correlates with tumor growth, invasion and metastasis. Although tumor blood flow increased by angiogensis, it has not been established to noninvasively measure tumor blood flow in vivo. In this research project, we have developed a new method for quantitative measurement of tumor blood flow(TBF) in vivo by using dynamic contrast-enhanced magnetic resonance imaging(MRI) and compartment analysis. Dynamic contrast-enhanced MRI was performed using inversion recovery-preparation fast field echo(IR-FFE) sequence(TR/TE/TT 7.7/3.9/280msec, flip angle 10 degree, FOV 380x190mm, matrix 256x128, slice thickness 6mm). Quantitative TBF maps(ml/100ml/min) were generated pixel-by-pixel by deconvolution analysis of the signal intensity-time curves obtained from arteries and tumors. TBF map clearly demonstrated heterogeneity ofTBF, i.e. increased TBF in tumor periphery due to angiogenesis and low TBF in center of tumor. In patients who received chemotherapy, substantial changes of TBF were demonstrated after chemotherapeutic cycles, reflecting the therapeutic response. On surgical specimens, the distribution of viable and non-viable tumor cells and the chemotherapeutic effects were better predicted by the TBF maps rather than the conventional contrast-enhanced T1-weighted MR images. Thus, TBF map would be a promising tool for evaluating tumor blood flow and may be useful to evaluate treatment response.

血管生成与肿瘤生长、侵袭和转移相关。虽然肿瘤血流量增加血管生成，它还没有建立在体内无创测量肿瘤血流量。在本研究项目中，我们开发了一种新的方法，定量测量肿瘤血流量（TBF）在体内使用动态对比增强磁共振成像（MRI）和房室分析。使用反转恢复-准备快速场回波（IR-FFE）序列（TR/TE/TT 7.7/3.9/280 msec，翻转角10 °，FOV 380 x 190 mm，矩阵256 x 128，层厚6 mm）进行动态对比增强MRI。通过对从动脉和肿瘤获得的信号强度-时间曲线进行去卷积分析，逐像素生成定量TBF图（ml/100 ml/min）。TBF图显示肿瘤周围TBF因血管生成而增加，而肿瘤中心TBF较低。在接受化疗的患者中，化疗周期后TBF发生了实质性变化，反映了治疗反应。在手术标本上，TBF图比传统的对比增强T1加权MR图像更好地预测了存活和非存活肿瘤细胞的分布以及化疗效果。因此，TBF图将是一个有前途的工具，用于评估肿瘤血流，并可能是有用的，以评估治疗反应。

项目成果

Sugawara Y, Murase K, Kikuchi K, Mochizuki T, et al.: "Usefulness of functional tumor blood flow map generated by dynamic contrast-enhanced MRI and deconvolution analysis."Radiology. 698. 229 (2003)

Sukawara Y、Murase K、Kikuchi K、Mochizuki T 等人：“通过动态对比增强 MRI 和反卷积分析生成的功能性肿瘤血流图的有用性。”放射学。

Sugawara Y, et al.: "Usefulness of functional tumor blood flow map generated by dynamic contrast-enhanced MRI and deconvolution analysis"Radiology. 229(P). 698 (2003)

Sukawara Y 等人：“通过动态对比增强 MRI 和反卷积分析生成的功能性肿瘤血流图的有用性”放射学。

Sugawara Y, Murase K, Kikuchi K, Mochizuki T, et al.: "Quantitative measurement of tumor blood flow using dynamic MRI and deconvolution analysis."Radiology. 270. 225 (2002)

Sukawara Y、Murase K、Kikuchi K、Mochizuki T 等人：“使用动态 MRI 和反卷积分析定量测量肿瘤血流。”放射学。

Sugawara Y, Murase K, Kikuchi K, Mochizuki T, et al.: "Assessment of functional map in musculoskeletal tumors : comparison of tumor blood flow by dynamic MRI and ^<201>T1 scintigraphy."J Nucl Med. 44. 408 (2003)

Sukawara Y、Murase K、Kikuchi K、Mochizuki T 等人：“肌肉骨骼肿瘤功能图的评估：通过动态 MRI 和 ^<201>T1 闪烁扫描法比较肿瘤血流。”J Nucl Med。

Sugawara Y, et al.: "Assessment of tumor blood flow in musculoskeletal tumors : a novel approach with dynamic MRI and thallium-201 scintigraphy"Radiology. 225(P). 734 (2002)

Sukawara Y 等人：“肌肉骨骼肿瘤中肿瘤血流的评估：动态 MRI 和铊 201 闪烁扫描的新方法”放射学。