Neurocognitive function of patients with obsessive-compulsive disorder (OCD) : A functional MRI study comparing patients with OCD with Normal Controls during Chinese character Stroop task

强迫症 (OCD) 患者的神经认知功能：在汉字 Stroop 任务中比较强迫症患者与正常对照的功能性 MRI 研究

• 批准号: 14570931
• 负责人: NAKAGAWA Akiko
• 金额: $ 1.73万
• 依托单位: Kawasaki Medical School (2004)Kyushu University (2002-2003)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570931/
• 关键词: obsessive-compilsive disorder; cognitive function; neuropsychological test; functional MRI; action-monitoring function; selective attention; Stroop test; caudate nucleus; 前頭眼窩面; Stroop Test

Recent functional neuroimaging and neuropsychological studies have implicated that frontal cortex and subcortical structures may play a substantial role in the pathophysiology of OCD. To identify the relationship between brain dysfunction and cognitive dysfunction, we examined the regional brain changes in OCD by using functional MRI (fMRI) while a cognitive task is being undertaken. Thirty-one patients with OCD and nineteen normal controls participated in the study. First, we compared their cognitive function by several neuropsychological tests. Then we examined them fMRI during the Chinese character version Stroop task that is strongly related with action-monitoring function. On all the neuropsychological tests, there were no significant differences between the two groups. In fMRI, both the two groups showed similar activation pattern. The patients, however, showed weaker activation than the normal controls in the right caudate nucleus than the normal controls. It was suggested that OC symptoms might be related to abnormal activation in the caudate nucleus, though we were not able to find neuropsychological deficits of OCD.

最近的功能性神经影像学和神经心理学研究表明，额叶皮质和皮质下结构可能在强迫症的病理生理学中发挥重要作用。为了确定脑功能障碍和认知功能障碍之间的关系，我们使用功能磁共振成像（fMRI）检查了强迫症患者在进行认知任务时的脑局部变化。31名强迫症患者和19名正常对照参与了这项研究。首先，我们比较了他们的认知功能的神经心理测试。然后，我们在汉字版Stroop任务中检测了与动作监测功能密切相关的fMRI。在所有的神经心理测试中，两组之间没有显著差异。在fMRI中，两组均表现出相似的激活模式。然而，与正常对照组相比，患者的右侧尾状核的激活较弱。虽然我们没有发现强迫症的神经心理学缺陷，但我们认为，强迫症的症状可能与尾状核的异常激活有关。

项目成果

Nakatani E, Nakagawa A, Ohara Y, et al.: "Effects of behavior therapy on regional cerebral blood flow in obsessive-compulsive disorder"Psychiatry Research : Neuroimaging. 124. 113-120 (2003)

Nakatani E、Nakakawa A、Ohara Y 等人：“行为疗法对强迫症局部脑血流的影响”精神病学研究：神经影像学。

鍋山麻衣子, 中谷江利子, 中尾智博他: "治療指針のための強迫性障害の臨床研究-行動療法、薬物療法の治療効果比較検討-.第29回日本行動療法学会抄録集pp172-173"2 (2003)

Maiko Nabeyama、Eriko Nakatani、Tomohiro Nakao 等：《强迫症治疗指南的临床研究 - 行为疗法和药物疗法治疗效果的比较研究 -》第 29 届日本行为治疗学会摘要第 172-173 页” 2（2003）

Action-monitoring function of obsessive-compulsive disorder (OCD): A functional MRI study comparing patients with OCD with Normal Controls during Chinese character Stroop task

强迫症 (OCD) 的动作监测功能：在汉字 Stroop 任务中比较强迫症患者与正常对照的功能 MRI 研究

• 发表时间: 2005
• 期刊: Psychiatry res neuroimaging 139
• 作者: Nakao T;Nakagawa A;Yoshiura T;et al.
• 通讯作者: et al.

強迫性障害の精神療法・行動療法

强迫症的心理治疗和行为治疗

• 发表时间: 2004
• 期刊: 精神科 第5巻第2号
• 作者: 鍋山麻衣子

中尾智博, 中川彰子: "強迫性障害の認知機能"精神医学. 44巻10号. 1044-1054 (2002)

Tomohiro Nakao、Akiko Nakakawa：“强迫症中的认知功能”，《精神病学》第 44 卷，第 10 期。1044-1054 (2002)