CHANGE OF BRAIN FUNCTION ALONG WITH TREATMENT EFFECT IN PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDRDER ; AN FUNCTIONAL MRI STUDY

我们通过Stroop试验评估可能与强迫症症状相关的抑制过程，研究了接受BT、氟伏沙明(Flv)治疗的强迫症患者和对照治疗的脑变化的差异。结果，在比较FLV组和对照组的分析中，只检测到右侧背外侧前额叶皮质(DLPFC)。该区域(不是右侧，而是左侧)，以及其他几个在颞区和顶区的分析，在BT组和对照组之间也显示出显著的差异。DLPFC被认为是与强迫症的病理生理学相关的区域之一，特别是在计划执行功能方面。

We investigated the differences of brain change among OCD patients treated with BT, fluvoxamine (FLV), and control treatment using Stroop test assessing inhibition processes that might be related with OCD symptoms. As the result, only the right dorsolateral prefrontal cortex (DLPFC) was detected in analysis comparing the FLV group to the control group. The region( not right, but left), as well as other several ones in temporal and parietal area, showed significantly different change in analysis between the BT group and the control group, too. The DLPFC has been suggested as one of the regions related to the pathophysiology of OCD, especially in planning aspects of executive function.