The impact of early-life nutrition on socioeconomic status, physical health and cognitive function through middle age

项目摘要 营养是一项关键的人力资本投资，特别是在低收入和中等收入国家， 目前有数亿儿童营养不良，10亿多成年人营养不良 小时候先前的证据表明，生命早期营养不良与身体健康的负面影响有关。 健康、受教育程度、认知技能和工资率。考虑到身体健康和 认知功能随着年龄的增长而下降，重要的是要问早期营养是否会影响这些速度 下降。这是关于生命早期营养对寿命影响的一个重要知识缺口。该项目将 使用异常丰富的纵向数据从实验操纵的营养：危地马拉研究所 中美洲和巴拿马营养研究所（INCAP）营养补充试验队列（CNOC）。C是 1969年作为一项实验性的营养补充计划开始实施， 进行了。在拟议项目期间，队列成员将处于47-64岁的成年期， 在大多数低收入国家，生物和认知老化相当严重。 具体来说，该项目将探讨如何实验分配的早期生活营养补充影响 成年期（47-64岁）的社会经济、身体健康和认知功能结果水平， 从早期到成熟期的这些领域的变化。我们问：营养干预是否会影响 在成年早期观察到的现象在以后的年龄仍然存在吗？改善儿童营养是否会 随着参与者年龄的增长，这些结果会发生什么变化？我们将通过收集和分析一个 一套全面的社会经济地位，身体健康和认知功能的措施，其中许多 我们在先前的波中有测量。 由于童年的巨大后果，这项拟议中的研究具有很高的潜在影响力。 营养不良对数亿人的健康和人力资本的影响。该研究团队是独一无二的 非常有资格调查这一主题;团队成员对当前的知识做出了重大贡献， 营养在中低收入国家生命过程中的重要性。通过使用适当的计量经济学和生命周期人类 资本模型，充分利用幼儿数据，并在以前的研究基础上，该项目将 改变我们对生命早期营养的理解， 成熟的成年

PROJECT SUMMARY Nutrition is a key human capital investment, especially in low- and middle-income countries (LMICs), where hundreds of millions of children are currently undernourished and well over a billion adults were undernourished as children. Prior evidence indicates that early-life undernutrition is associated with negative effects on physical health, schooling attainment, cognitive skills and wage rates in young adulthood. Given that physical health and cognitive function decline with age, it is important to ask whether early-life nutrition affects the pace of these declines. This is a critical knowledge gap concerning the lifespan impacts of early-life nutrition. This project will use unusually rich longitudinal data from an experimental manipulation of nutrition: the Guatemalan Institute of Nutrition of Central America and Panama (INCAP) Nutrition Supplementation Trial Cohort (INSTC). INSTC was initiated in 1969 as an experimental nutritional-supplementation program and a number of follow-up rounds have been conducted. Cohort members will be in mature adulthood, 47-64 years of age, during the proposed project, ages at which biological and cognitive aging is considerable in most LMICs. Specifically, the project will explore how experimentally allocated early-life nutritional supplementation affects levels of socioeconomic, physical-health, and cognitive-function outcomes in mature adulthood (47-64 y) and changes in these domains from early to mature adulthood. We ask: Do the nutrition intervention impacts observed earlier in adulthood persist at later ages? Does improved childhood nutrition additionally impact changes in these outcomes as participants age? We will explore these questions by collecting and analyzing a comprehensive set of measures of socioeconomic status, physical health and cognitive function, many of which we have measures in prior waves. The proposed study has high potential impact because of the enormous consequences of childhood undernutrition for the health and human capital of hundreds of millions of people. The research team is uniquely well qualified to investigate this topic; team members have made major contributions to current knowledge about the importance of nutrition over the life-course in LMICs. By using appropriate econometrics and life-cycle human capital models, with full access to the early childhood data, and building on previous studies, the project will transform our understanding of early-life nutrition and the health, cognitive and socioeconomic outcomes of mature adulthood.