Molecular biological investigation of sleep disorders caused by involuntary movement during sleep.

我们治疗过许多患有睡眠障碍的病人。不宁腿综合征（RLS）是一种严重的睡眠障碍。多巴胺能化合物如左旋多巴胺和多巴胺受体激动剂被推荐用于RLS患者。一些引起RLS的原因已得到证实，但仍在讨论中。近年来，遗传方法在多巴胺能神经传递系统的研究中得到了应用。然而，他们无法定义基因包涵的关系。目前我们仍在从事精神病学领域的基因研究，因此我们对5 -羟色胺受体亚型（HT1A）多态性与睡眠障碍的关系进行了研究。我们没有发现任何积极的联系。现在我们的RLS患者规模较小，所以我们不能显示出统计学意义。

We have been treated patients suffering from many sleep disorders. A restless legs syndrome(RLS) is one of severe sleep disorders. Dopaminergic compounds such as L-DOPAs and dopamine receptor agonists are recommended to use the patints of RLS. Some causes of RLS are demonstrated but they are still under discussion. Recently genetic approaches have done by some researches in dopaminergic neuro-transmission system. However they couldn't define the relation of genetically inclusion. Still now we engaged a genetic research in psychiatric field, so we done an association study between serotonin receptor subtype (HT1A) polymorphism and sleep disorders. We couldn't detect a positive association. Now we have a small size of RLS patients, so we cannot show a statistical significance.