Establishment of a new multidisciplinary therapy with pre-operative laparoscopy and molecular diagnosis for peritoneal dissemination of advanced gastric cancer.

建立一种新的多学科治疗方法，包括术前腹腔镜检查和分子诊断，治疗晚期胃癌的腹膜播散。

• 批准号: 14571194
• 负责人: FUJIWARA Yoshiyuki
• 金额: $ 2.24万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571194/
• 关键词: advanced gastric cancer; peritoneal dissemination; molecular diagnosis; micrometastasis; laparoscopy; chemotherapy; 胃癌; 腹膜播腫; 腹腔鏡; 腹腔洗浄液

1, We have developed molecular diagnosis for micrometastasis in peritoneal lavage fluids of gastric cancer patients (Int.J.Oncol,2003).2, We introduced pre-operative laparoscopy and molecular diagnosis with peritoneal lavage fluids for advanced gastric cancer. Pre-operative intra-operative chemotherapy was performed for serosa-invaded gastric cancer cases. These results showed that if molecular diagnosis changed from micrometastasis positive to negative, the prognosis of the patient was improved (Ann.Surg.Oncol,2004).3, The pilot study of a new multidisciplinary therapy was performed for 60 cases with advanced gastric cancer. This study showed that pre-operative chemotherapy for high-risk patients of peritoneal recurrence was beneficial and the patients with molecular diagnosis (-) had a better prognosis.4, In conclusion, the new multidisciplinary therapy combined with laparoscopy and molecular diagnosis will be effective for far-advanced gastric cancer patients.

1、建立了胃癌腹腔灌洗液微转移的分子诊断方法（Int. J. Oncol，2003）。2、介绍了腹腔镜术前检查及腹腔灌洗液分子诊断进展期胃癌。对浸润浆膜的胃癌患者术前行术中化疗。这些结果表明，如果分子诊断从微转移阳性转为阴性，患者的预后会得到改善（Ann. Surg. Oncol，2004）。3、对60例进展期胃癌患者进行了新的多学科治疗的初步研究。本研究表明术前化疗对腹腔复发高危患者是有益的，分子诊断（-）的患者有更好的预后。4、结论腹腔镜联合分子诊断的多学科治疗对晚期胃癌患者是有效的。

项目成果

藤原義之, 谷口博一, 他: "術前腹腔内化学療法施行後胃切除を施行された症例で早期に癌性イレウス症状を来した2症例の検討"癌と化学療法. 30(11). 1614-1617 (2003)

Yoshiyuki Fujiwara、Hirokazu Taniguchi 等人：“术前腹腔化疗后胃切除术后早期出现癌性肠梗阻症状的两例回顾”，Cancer and Chemotherapy 30(11) (2003)。

Mori T.: "Prevention of peritoneal metastasis of human gastric cancer cells in nude mice by S-1, a novel oral derivative of 5-Fluorouracil"Oncology. 64(2). 176-182 (2003)

Mori T.：“通过 S-1（一种新型 5-氟尿嘧啶口服衍生物）预防裸鼠体内人胃癌细胞的腹膜转移”肿瘤学。

Yoshioka S., Fujiwara Y., et al.: "Real-time rapid reverse transcriptase polymerase chain reaction for intraoperative diagnosis of lymph node micrometastasis : Clinical application for cervical lymph node dissection in esophageal cancers."Surgery. 132(1).

Yoshioka S.、Fujiwara Y.等人：“实时快速逆转录酶聚合酶链反应用于术中诊断淋巴结微转移：食管癌颈部淋巴结清扫术的临床应用。”外科。

Sugita Y, Fujiwara Y. et al.: "Quantitative molecular diagnosis of peritoneal lavage fluid for prediction of peritoneal recurrence in gastric cancer."Int J Oncol. 23(5). 1419-1423 (2003)

Sugita Y、Fujiwara Y. 等人：“腹膜灌洗液的定量分子诊断用于预测胃癌腹膜复发。”Int J Oncol。

Yoshioka S.: "Real-time rapid reverse transcriptase-polymerase chain reaction for intraoperative diagnosis of lymph node micrometastasis : clinical application for cervical lymph node dissection in esophageal cancers"Surgery. 132(1). 34-40 (2002)

Yoshioka S.：“实时快速逆转录聚合酶链反应术中诊断淋巴结微转移：食管癌颈部淋巴结清扫术的临床应用”。