Effects of development, maturation, and aging on neural control of upper airway

发育、成熟和衰老对上呼吸道神经控制的影响

• 批准号: 14571421
• 负责人: ISHIKAWA Teruhiko
• 金额: $ 2.24万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571421/
• 关键词: larynx; airway protective reflex; development and maturation; pharyngeal patency; sevoflurane; children; mandibular advancement; prone position; 発達; 成熟; 成長; 上気道; 麻酔

(1)In previous our study, we reported that collapsibility of the passive pharynx of infants decreases with their development. In the current study, we examined effects of prone position on the collapsibility of passive pharynx including infants and small children. We found the collapsibility was larger in prone position than in supine position. The developmental changes observed in the previous study were kept only in supine position. Published in Am.J.Respir.Grit.Care.Med 2002;166:760-764(2)Research for airway protective reflexes in childrenWe examined airway protective reflexes elicited by laryngeal distilled water instillation into the larynx under sevoflurane general anesthesia in children aged from 2 mo to 11 ys). Increasing depth of sevoflurane anesthesia form F_<ET_<sevo>> of 1% to that of 2% resulted in reduction in incidence of active reflexes (swallowing reflex, cough and/or expiration reflex), whereas passive reflexes (apnea, laryngeal closure, laryngospasm) were hardly affected. Maturational effects were not observed in this age category. Submitted to Anesthesiology(3)Effects of mandibular advancement on laryngeal view during direct laryngoscopy.Mandibular advancement improved laryngeal view during laryngoscopy. The authors concluded that it has clinical significance since the effect was no less good than that of BURP maneuver. The combination of mandibular advancement and BURP maneuver provided the most excellent laryngeal view. Published in Anesthesiology 2004;100:598-603.

(1)在我们之前的研究中，我们报道了婴儿被动咽部的湿陷性随着他们的发育而降低。在目前的研究中，我们检查了俯卧位对被动咽部塌陷的影响，包括婴儿和小孩。我们发现俯卧位的溃散性比仰卧位大。先前研究中观察到的发育变化仅在仰卧位时保持。发表于am . j . breathe . grit . care . med 2002；166:760-764(2)儿童气道保护反射的研究我们观察了在七氟醚全身麻醉下喉内注入蒸馏水引起的2月龄至11岁儿童气道保护反射。七氟醚麻醉深度从F_<ET_<sevo>>的1%增加到2%，可使主动反射（吞咽反射、咳嗽和/或呼气反射）的发生率降低，而被动反射（呼吸暂停、喉闭、喉痉挛）的发生率几乎不受影响。在这一年龄组中未观察到成熟效应。(3)直接喉镜下下颌前移对喉部观察的影响。下颌前移改善喉镜检查时喉部视野。结论：其效果不亚于BURP手法，具有临床意义。下颌前移和BURP手法的结合提供了最佳的喉部视野。麻醉学杂志2004；100:598-603。

项目成果

Ishikawa, T., Isono, S.et al.: "Prone position increases collapsibility of the passive pharynx in infants and small children"Am.J.Respir.Crit Care Med.. 5. 760-764 (2002)

Ishikawa, T., Isono, S.等人：“俯卧位会增加婴儿和幼儿被动咽部的塌陷”Am.J.Respir.Crit Care Med.. 5. 760-764 (2002)

Tamura, M., Ishikawa, T.et al.: "Mandibular Advancement Improves the Laryngeal View during Direct Laryngoscopy Performed by Inexperenced Physicians"Anesthesiology. 100. 598-603 (2004)

Tamura, M., Ishikawa, T.等人：“下颌前移改善了由经验不足的医生进行的直接喉镜检查期间的喉部视野”麻醉学。

Ishikawa, T., Isono, S., Aiba, J., Tanaka, A., Nishino, T.: "Prone position increases collapsibility of the passive pharynx in infants and small children"Am. J. Respir. Crit Care Med.. 166. 760-764 (2002)

Ishikawa, T.、Isono, S.、Aiba, J.、Tanaka, A.、Nishino, T.：“俯卧位会增加婴儿和幼儿被动咽部的塌陷性”Am。

Ishikawa, T., Isono, S., Aiba, J., Tanaka, A., Nishino, T.: "Prone position increases collapsibility of the passive pharynx in infants and small children"Am.J.Respir.Crit.Care.Med.. 166(5). 760-764 (2002)

Ishikawa, T.、Isono, S.、Aiba, J.、Tanaka, A.、Nishino, T.：“俯卧位会增加婴儿和幼儿被动咽部的塌陷”Am.J.Respir.Crit.Care。

Tamura, M., Ishikawa, T., Kato, R., Isono, S., Nishino, T.: "Mandibular Advancement Improves the Laryngeal View during Direct Laryngoscopy Performed by Inexperienced Physicians"Anesthesiology. 100(3). 598-603 (2004)

Tamura, M.、Ishikawa, T.、Kato, R.、Isono, S.、Nishino, T.：“下颌前移改善了缺乏经验的医生进行直接喉镜检查时的喉部视野”麻醉学。