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A research for establishing non-invasive circulatory monitoring using the index of cardiovascular coupling

利用心血管耦合指标建立无创循环监测的研究

基本信息

批准号：
14571457
负责人：
HAYASHI Kazuko
金额：
$ 2.62万
依托单位：
Kyoto Prefectural University of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571457/
关键词：
Ventricular Arterial Coupling Ees Ea Transfer Function second order response 4-element model Augmentation Index Efficiency of ventricular ejection Ejection Fraction システム同定特性インピーダンスコンプライアンス末梢血管抵抗 Augmentation Index 脈波伝搬速度動

项目摘要

We compared Ees/Ea with other general circulatory monitoring, and made clear the significance of Ees/Ea as circulatory monitoring. In myocardial infarction group, Ees/Ea value was significantly smaller (0.87±0.07), in comparison with hypertension group (1.46±0.29) and healthy group (2.17±0.29). On the other hand, as for augmentation index and pulse wave velocity, the significant difference was not recognized between myocardial infarction group and hypertension group. Thus, it was suggested that the integrated cardiovascular function, which was not provided from other indexes, can be measured with present methods. Furthermore, Ees/Ea measured by the present method correlated with the ejection fraction measured by an echocardiography (R=0.79; RMSE=0.08). In addition, the normal Ees/Ea range measured by the present method, agreed to a reported range measured by conventional methods. In the child group, Ees/Ea was slightly larger than the adult group, although the significant difference was not observed. Thus, the Ees/Ea measurement by this calculation method is expected to become the superior index, which distinguishes the cardiovascular function. In a study of monitoring Ees/Ea from periphery radial arterial pressure, we used 4 elements (arterial compliance, peripheral resistance, aortic characteristic impedance, inertia) for arterial vascular system, and examined the nature of pressure transmitting by 4 elements. As a result, aortic waveform was estimated from radial arterial pressure with the model transfer function which satisfied the circulatory dynamics. This study was an important strategy to estimate aortic pressure waveform from periphery radial arterial pressure waveform under various circulatory dynamics, which is important for on-line estimation of cardiovascular performance.

并将Ees/Ea与其他常规循环监测进行了比较，明确了Ees/Ea作为循环监测的意义。心肌梗死组Ees/Ea值（0.87±0.07）明显小于高血压组（1.46±0.29）和健康组（2.17±0.29）。而心肌梗死组与高血压组的增强指数和脉搏波传导速度无显著性差异。因此，可以用现有的方法来测量心血管综合功能，而这是其他指标所不能提供的。此外，本方法测量的Ees/Ea与超声心动图测量的射血分数相关（R=0.79; RMSE=0.08）。此外，用本方法测得的正常Ees/Ea范围与用常规方法测得的报道范围一致。在儿童组中，Ees/Ea略大于成人组，但未观察到显著差异。因此，通过该计算方法测量的Ees/Ea有望成为区分心血管功能的上级指标。在一项从外周桡动脉压监测Ees/Ea的研究中，我们将动脉血管系统的4个要素（动脉顺应性、外周阻力、主动脉特征阻抗、惯性）用于研究，并考察了4个要素的压力传递性质。结果表明，该模型的传递函数满足循环动力学要求，可以从桡动脉压中估计出主动脉波形。本研究是在不同循环动力学条件下由外周桡动脉压波形估计主动脉压波形的重要策略，对心血管性能的在线估计具有重要意义。