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Analysis for Estrogen Receptors Detected on the Rheumatoid Arthritis Synovial Cells by Immunofluorescent Bioimaging

Analysis for Estrogen Receptors Detected on the Rheumatoid Arthritis Synovial Cells by Immunofluorescent Bioimaging
免疫荧光生物成像分析类风湿性关节炎滑膜细胞上的雌激素受体
批准号:
14571796
负责人:
SUENAGA Shigeaki
金额:
$1.92万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2002
资助国家:
日本
项目状态:
已结题
起止时间:
2002 至 2003

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中文摘要
翻译
本研究的目的是假设17β-雌二醇(雌激素)可以调节成纤维细胞样滑膜细胞中活性氧(ROS)的产生和活性、一氧化氮(NO)的合成和脂质过氧化,其作用依赖于雌激素受体α (ER-α)的表达。结果表明,细胞因子和雌激素联合处理高ER-α表达的成纤维细胞,可减少细胞内ROS和NO的生成、脂质过氧化的产生,从而防止凋亡细胞死亡,而低ER-α表达的成纤维细胞则无明显变化。iNOS mRNA水平实验证实了NO水平。这些结果表明,雌激素通过控制NO和ROS的生成以及脂质过氧化作用,在保护细胞免受细胞因子诱导的细胞死亡中起重要作用。
英文摘要
The aim of this investigation was to hypothesize that 17β-estradiol(estrogen)can modulate the production and activity of reactive oxygen species(ROS), nitric pxide(NO)synthasis, and lipid peroxidation in fibroblast-like synovial cells, and the effects are dependent on the expressions of estrogen receptor alpha(ER-α).The results showed that the combined treatment of cytokines and estrogen for the high ER-α expressed fibroblasts decreased the intracellular ROS and NO generation, lipid peroxidation production and subsequent prevented apoptotic cell death, although the low expressed ER-α cells did not show the substantial change.The experiments on levels of iNOS mRNA confirmed the NO levels.These results suggest that estrogen plays an important role in protecting cells against cytokine-induced cell death by controlling the generation of NO and ROS and lipid peroxidation.
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Roles of expressions of estrogen receptor against ROS production in estrogen-dependent diseases
  • 批准号:
    22592094
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.41万
  • 财政年份:
    2010
  • 负责人:
    SUENAGA Shigeaki
  • 依托单位:
Effects of manganese superoxide dismutase(MnSOD)against mitochondrial reactive oxidative species and apoptotic cell deaths in RA synovial fibroblasts
  • 批准号:
    19592175
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.58万
  • 财政年份:
    2007
  • 负责人:
    SUENAGA Shigeaki
  • 依托单位:
Prevention of Nitric Oxide Production and Cell Deaths by Estrogen in Estrogen Receptor Expressed Rheumatoid Arthritis Fibroblasts
  • 批准号:
    16591891
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.86万
  • 财政年份:
    2004
  • 负责人:
    SUENAGA Shigeaki
  • 依托单位:
Study on Molecular Mechanism for the Intra-Articular Lesions of Temporo-mandibular Joint Disorders by Estrogen Hormonal Changes During the Menstrual Cycle
  • 批准号:
    12671833
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.05万
  • 财政年份:
    2000
  • 负责人:
    SUENAGA Shigeaki
  • 依托单位:
国内基金
海外基金
Estrogen/NDRG2/Na+/K+-ATPase调控通路在唾液生成和雌激素缺乏诱发口干症中的作用研究