Roles of expressions of estrogen receptor against ROS production in estrogen-dependent diseases
Roles of expressions of estrogen receptor against ROS production in estrogen-dependent diseases
批准号:
22592094
负责人:
SUENAGA Shigeaki
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
We examined the expressions of estrogen receptor, the production and activity of mitochondrial reactive oxygen species (ROS), lipid peroxidation and apoptosis following a cytokine plus estrogen (dose: 10-10M~10-4M) treatment in human normal fibroblasts, RA fibroblasts, VA-13, MCF-7, and MDA-MB453 cells. The oxidant and anti-oxidant effects of estrogen on the ROS generation, lipid peroxidation product, and subsequent apoptotic cell death depended on cell types, expressions of estrogen receptor (α, β), doses of estrogen.
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口腔扁平上皮癌における所属リンパ節転移の画像診断精度-造影CT,USおよびPETによる評価-.
口腔鳞状细胞癌区域淋巴结转移影像诊断的准确性——增强CT、超声和PET的评估。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[末永重明, 犬童寛子, 川畑義裕, 河野一典, 佐藤強志, 比地岡浩志, 中村典史, 仙波伊知郎, 馬嶋秀行, 末永重明,犬童寛子,川畑義裕,河野一典,佐藤強志,比地岡浩志,中村典史,仙波伊知郎,馬嶋秀行]
通讯作者:
末永重明,犬童寛子,川畑義裕,河野一典,佐藤強志,比地岡浩志,中村典史,仙波伊知郎,馬嶋秀行
口腔扁平上皮癌における所属リンパ節転移の画像診断精度-造影CT、USおよびPETによる評価-
口腔鳞状细胞癌区域淋巴结转移的影像准确性-增强CT、US和PET评估-
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[末永重明, 犬童寛子, 川畑義裕, 河野一典, 佐藤強志, 比地岡浩志, 中村典史, 仙波伊知郎, 馬嶋秀行]
通讯作者:
馬嶋秀行
Nitric- and oxidative mitochondria related cell death by cytokines and its prevention by estrogen in estrogen receptor expressed rheumatoid arthritis synovial fibroblasts
雌激素受体表达的类风湿性关节炎滑膜成纤维细胞中细胞因子引起的与氮和氧化线粒体相关的细胞死亡及其雌激素的预防
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Suenaga S, Indo HP, Tomita K, Ijiri K,Komiya S, Yen H-C, Higuchi M, MatsuiH., Ozawa T, Majima HJ]
通讯作者:
Majima HJ
Induction of mitochondrial ROS and cell death by cytokines and its prevention by estrogen in rheumatoid arthritis fibroblasts
类风湿性关节炎成纤维细胞中细胞因子诱导线粒体ROS和细胞死亡及其雌激素的预防
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Shigeaki Suenaga, Hiroko P. Indo, Hsiu-Chuan Yen, Kosei Ijiri, Setsuro Komiya, Takami Matsuyama, Masahiro Higuchi, Hirofumi Matsui, Toshihiko Ozawa, Hideyuki J. Majima]
通讯作者:
Hideyuki J. Majima
Nitric- and oxidative mitochondria related cell death by cytokines and its prevention by estrogen in estrogen receptor expressed rheumatoid arthritis synovial fibroblasts.
细胞因子导致的氮和氧化线粒体相关的细胞死亡以及雌激素受体表达的类风湿性关节炎滑膜成纤维细胞中雌激素对其的预防。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Suenaga S, Indo HP, Tomita K, Ijiri K, Komiya S, Yen H-C, Higuchi M, Matsui H, Ozawa T, Majima HJ.]
通讯作者:
Majima HJ.
Effects of manganese superoxide dismutase(MnSOD)against mitochondrial reactive oxidative species and apoptotic cell deaths in RA synovial fibroblasts
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批准号:19592175
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.58万
-
财政年份:2007
-
负责人:SUENAGA Shigeaki
-
依托单位:
Prevention of Nitric Oxide Production and Cell Deaths by Estrogen in Estrogen Receptor Expressed Rheumatoid Arthritis Fibroblasts
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批准号:16591891
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.86万
-
财政年份:2004
-
负责人:SUENAGA Shigeaki
-
依托单位:
Analysis for Estrogen Receptors Detected on the Rheumatoid Arthritis Synovial Cells by Immunofluorescent Bioimaging
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批准号:14571796
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:2002
-
负责人:SUENAGA Shigeaki
-
依托单位:
Study on Molecular Mechanism for the Intra-Articular Lesions of Temporo-mandibular Joint Disorders by Estrogen Hormonal Changes During the Menstrual Cycle
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批准号:12671833
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.05万
-
财政年份:2000
-
负责人:SUENAGA Shigeaki
-
依托单位:
海外基金