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SAFETY AND QUALITY OF RECOVERY FROM PROPOFOL ANESTHESIA-THE EFFECTS OF AMINOPHYLLINE-

丙泊酚麻醉恢复的安全性和质量 - 氨茶碱的影响 -

基本信息

批准号：
14571912
负责人：
SAKURAI Satoru
金额：
$ 2.24万
依托单位：
Tokyo Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571912/
关键词：
aminophylline propofol recovery 覚醒アデノシンフェンタニール全身麻酔

项目摘要

1.Recovery from propofol/fentanyl anesthesia : Aminophylline (5mg/kg) resulted in earlier recovery of proper response to command, and earlier recovery of orientation. It also resulted in patients' higher performances in cognitive function tests at 15 and 30 min after propofol anesthesia.2.Recovery from propofol/nitrous oxide anesthesia : Aminophylline(5mg/kg) resulted in earlier awakening at higher plasma propofol concentration, earlier recovery of proper response to command, and earlier recovery of orientation. It also resulted in patients' higher performances in cognitive and psychomotor function tests at 15 and 30 min after propofol anesthesia.3.Recovery from propofol sedation : Psychomotor function (Triger Dot Test), motor equilibrium function (fluctuation of the center of gravity) improved significantly in those receiving aminophylline. At 5 min after discontinuation of propofol, the value of end-tidal CO_2 was significantly lower in those receiving aminophylline.No adverse side effect of increased serum theophylline concentration was observed.Aminophylline, an adenosine receptor antagonist, reversed most of the effects of propofol. Reversal effects by aminophylline may be mediated by antagonistic actions at adenosine receptors specifically involved in the anesthetic and sedative action of propofol. The results of the present study indicate that aminophylline is useful in facilitating recovery from propofol anesthesia and in increasing vigilance in the early postoperative period when used at emergence from anesthesia.

1.异丙酚/芬太尼麻醉恢复：氨茶碱（5 mg/kg）使对命令的正确反应和定向力恢复更早。异丙酚/笑气麻醉后恢复：氨茶碱（5 mg/kg）可使异丙酚血药浓度较高时患者苏醒早，对指令的正确反应恢复早，定向力恢复早。3.异丙酚镇静后恢复：氨茶碱组患者的精神功能（触发点试验）、运动平衡功能（重心波动）明显改善。停药后5 min，氨茶碱组呼气末CO_2明显降低，未观察到茶碱血药浓度升高的副作用，腺苷受体拮抗剂氨茶碱可逆转大部分效应。氨茶碱的抑制作用可能是通过对腺苷受体的拮抗作用介导的，而腺苷受体与丙泊酚的麻醉和镇静作用密切相关。本研究的结果表明，氨茶碱是有用的，以促进从丙泊酚麻醉恢复和提高警惕，在术后早期，当从麻醉中出现。