SAFETY AND QUALITY OF RECOVERY FROM PROPOFOL ANESTHESIA-THE EFFECTS OF AMINOPHYLLINE-

1.异丙酚/芬太尼复合麻醉苏醒：氨茶碱(5 mg/kg)可提前恢复对指令的正确反应，提前定向力恢复。2.异丙酚/一氧化二氮复合麻醉苏醒：氨茶碱(5 mg/kg)可使患者在较高异丙酚血药浓度时较早苏醒，较早恢复对指令的正确反应，较早恢复定向。在异丙酚镇静后15分钟和30分钟，患者的认知和精神运动功能表现更好。3.异丙酚镇静恢复：精神运动功能(Triger Dot试验)、运动平衡功能(重心波动)在接受氨茶碱治疗后显著改善。停用异丙酚5分钟后，接受氨茶碱治疗的患者呼气末二氧化碳分压明显降低，未观察到茶碱血药浓度升高的不良反应，腺苷受体拮抗剂氨茶碱逆转了异丙酚的大部分作用。氨茶碱的逆转作用可能是通过与异丙酚的麻醉和镇静作用有关的腺苷受体的拮抗作用来实现的。本研究结果表明，氨茶碱可促进异丙酚的麻醉恢复，并可提高术后早期苏醒时的警觉性。

1.Recovery from propofol/fentanyl anesthesia : Aminophylline (5mg/kg) resulted in earlier recovery of proper response to command, and earlier recovery of orientation. It also resulted in patients' higher performances in cognitive function tests at 15 and 30 min after propofol anesthesia.2.Recovery from propofol/nitrous oxide anesthesia : Aminophylline(5mg/kg) resulted in earlier awakening at higher plasma propofol concentration, earlier recovery of proper response to command, and earlier recovery of orientation. It also resulted in patients' higher performances in cognitive and psychomotor function tests at 15 and 30 min after propofol anesthesia.3.Recovery from propofol sedation : Psychomotor function (Triger Dot Test), motor equilibrium function (fluctuation of the center of gravity) improved significantly in those receiving aminophylline. At 5 min after discontinuation of propofol, the value of end-tidal CO_2 was significantly lower in those receiving aminophylline.No adverse side effect of increased serum theophylline concentration was observed.Aminophylline, an adenosine receptor antagonist, reversed most of the effects of propofol. Reversal effects by aminophylline may be mediated by antagonistic actions at adenosine receptors specifically involved in the anesthetic and sedative action of propofol. The results of the present study indicate that aminophylline is useful in facilitating recovery from propofol anesthesia and in increasing vigilance in the early postoperative period when used at emergence from anesthesia.