Participation of the adenosine receptor for recovery effect from sedation/hypnosis

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Sedative/hypnotic effect of midazolam involved Gamma-aminobutyric acid receptor.Moreover, midazolam increases adenosine level in Central Nervous System. Since adenosine receptors are involved in natural sleep, sedation/ hypnosis occurs by adenosine increase in Central Nervous System. Aminophylline, an adenosine receptor antagonist, reversed sedative effects of midazolam. Reversal effects by aminophylline may be mediated by antagonistic actions at adenosine receptors. Thus adenosine receptor may be involved in sedation/hypnotic effect of midazolam.