Development of computer software 'GenDis English version' for the diagnosis of genetic diseases.

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(1)Making a database for genetic diseasesThe huge old data included in UR-DBMS(University of the Ryukyus-Database for malformation syndromes) had been revised mainly through Internet(OMIM) to the end of March 2004. As a result, newest database was accomplished for about 7,900 diseases and/or loci in several files(main UR-DBMS, reference, abstract, cDNA, mutation etc.). Total volume of this UR-DBMS Ver.11 exceeded more than 750 MB.(2)Development of new original software for EnglishThe operating program of my original software 'GenDis', for making a diagnosis of genetic diseases using Japanese-OS computers, was rewrote in English to enable to use it in English-OS computers. This software was newly named as 'Syndrome Finder' to distinguish it from original Japanese 'GenDis'. The data of clinical findings in UR-DBMS Ver.11 were taken into the finding data field of 'Syndrome Finder'. Finally, 'Syndrome Finder' software had an ability to select candidate diseases or syndromes in the order of its probability after inputting patient's full manifestations.English Syndrome Finder was started opening to the public from April of 2003,and presented in 52nd Annual Meeting of American Society of Human Genetics. Syndrome Finder was requested to use from 63 specialized hospitals for genetic clinics in Japan. Much newer 'Syndrome Finder 2' has been opened from April of 2004.