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Influence of exercise induced muscle injury on functional regeneration.

运动引起的肌肉损伤对功能再生的影响。

基本信息

批准号：
14580026
负责人：
KASUGA Norikatsu
金额：
$ 2.24万
依托单位：
AICHI UNIVERSITY OF EDUCATION
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

In this studie was designed to correlate muscle injury following eccentric contraction with denervation and reinnervatin, and to examine the impact of nerve freezing on the neuromuscular system after temporary denervation. The great plasticity of muscle can well be demonstrated in the hypertrophy and the transformation by changed the neuronal control. On the other hand, muscle damage occurs after any form of eccentric contractions or high-intensity exercise. The muscle damage may lead to denervate by disruption of neuromuscular junction portion. The axonal sprouting and formation of new synapses were observed as a result of muscle damage. Therefore, regeneration of the injured muscle may significantly affect the changing of fibre type, and the marked degree of fibre type grouping and markedly smaller myofibers were observed in reinnervated muscle. The smaller myofibers may have normal functional properties, except for capability of hypertrophy regulation. On the otherhand, ischiadic nerve freezing resulted in total lack of neuromuscular transmission followed by a slow recovery. Muscle injury by muscle contusion with nerve freezing encouraged the early recovery. Immunochemical observations show that rapid and prominent upregulation of cytokines in motoneurons at initialstage of reinnervation is important for the regeneration of neuromuscular junction.

本研究旨在将离心收缩后的肌肉损伤与去神经支配和再神经支配相关联，并检查暂时去神经支配后神经冷冻对神经肌肉系统的影响。肌肉的巨大可塑性可以通过改变神经元的控制而表现为肌肉的肥大和变形。另一方面，肌肉损伤发生在任何形式的离心收缩或高强度运动之后。肌肉损伤可通过神经肌肉接头部分的破坏而导致失神经支配。肌肉损伤后可观察到轴突出芽和新突触的形成。因此，损伤肌肉的再生可能显著影响肌纤维类型的变化，在再神经支配的肌肉中观察到明显程度的肌纤维类型分组和明显更小的肌纤维。较小的肌纤维可能具有正常的功能特性，除了肥大调节的能力。另一方面，坐骨神经冷冻导致神经肌肉传递的完全缺乏，随后恢复缓慢。肌肉挫伤伴神经冷冻引起的肌肉损伤促进了早期恢复。免疫组化观察表明，在神经再支配的初期，运动神经元细胞因子的迅速而显著的上调对神经肌肉接头的再生是重要的。