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EFFECTS OF EXERSICE STIMULATION ON RECOVERY FROM INJURED MUSCLE

运动刺激对受伤肌肉恢复的影响

基本信息

批准号：
11680022
负责人：
KASUGA Norikatsu
金额：
$ 2.18万
依托单位：
AlCHl UNIVERSITY OF EDUCATlON
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2001
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680022/
关键词：
INJURED MUSCLE ECCENTRIC CONTRACTION SKELETAL MUSCLE MUSCLE FIBER TYPE BRANCHED FIBER TRAINING EFFECT skinned flber 再生筋線維伸長性収縮

项目摘要

Physiological evidences suggests that contractile faillure from eccecntric contraction included muscle injury because structurral and motphorogical disruption.The pufpbse of this study was to examine the effect of various stimulations bn injured muscle regeneration. To study the process of morphorgical changes associated with degeneration and regeneration in piantaiis or extesor digitrum iongus muscle of rat, cyclic eccentric contraction, dowm -hill running or bupivacaine injection was induced.1) Significant number of damaged muscle fibers were found 3-5 days after eccentric contraction test. Three days after downhill running the tetanic tension by indirected stimulation was less than direct stimulate tension; and some neuromuscular junctions showed unfusimotor axons. The electron Microscopic observations suggest that the neuromuscular junctions regeneration depends on the remodeling of Synaptic membrane systems.2) The muscle main body was damaged easily by the overload in old muscle, and recovery speeds was slow, it suggested that especially the movement of the overload with aging progress should be avoided, an enough rest is needed when muscle was damaged.3) The voluntarily wheel running training caused a muscle damage consistent with the case of down-hill running in rat hindimb muscle and affected the transformation of muscle fiber types.4)increament of muscle fiber transformation occurred after detraining and bupivacaine induced injury and regeneration may have a role in the nerve conversion of the neuromuscular junction injury process.5 )Extensiye distribution of muscle fiber cross-sectional area, involved very small fiber observed, particularly in type Iib fiber recovery after injuy.

生理学证据表明，电收缩引起的收缩功能障碍包括结构和运动的破坏，本研究旨在探讨各种刺激对损伤肌肉再生的影响。本实验采用周期性离心收缩、下坡跑和布比卡因注射等方法，观察大鼠掌侧肌和趾长伸肌变性和再生的形态学变化过程。下坡跑后3天，间接刺激引起的强直性张力低于直接刺激引起的强直性张力，部分神经肌肉接头出现非融合运动轴突。电镜观察提示，神经肌肉接头的再生依赖于突触膜系统的重塑。2）老年肌肉的超负荷运动易使肌肉主体受损，且恢复速度慢，提示随着年龄的增长应避免超负荷运动。3）自行跑训练对大鼠后肢肌肉造成了与下坡跑一致的损伤，并影响了肌纤维类型的转化停训后肌纤维转化增加，布比卡因诱导的损伤与再生可能在神经肌肉接头损伤的神经转化过程中起作用。5）肌纤维横截面积分布广泛，所涉及的纤维非常小，尤其是Iib型纤维损伤后的恢复。