BIO-IMAGING OF SATELLITE CELL IN REGENERATING MUSCLE

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The recruitment of satellite cells, which are located between the basement membrane and the plasma membrane in myofibers, is controlled by muscle injury or overload, several growth factor. It is poorly understood how the satellite cell migration is involved in muscle regeneration after injury because in vivo it has been technically very difficult to visualize the living satellite cells localized. In the present study, by using quantum dots conjugated with an anti-M-cadherin antibody, we first demonstrated that the satellite cell migration toward the injured site was induced in the injured muscles, and toward the end of myofibers in early developing stage muscle. Thus, it was suggested that the satellite cell migration may be play important roles to regulate the muscle regeneration and development.