STUDIES ON FIBER TYPE TRANSFORMATION OF THE PROCESS OF SKELETAL MUSCLE INJURY AND REGENERATION AFTER ECCENTRIC EXERCISE.

偏心运动后骨骼肌损伤与再生过程中纤维类型转变的研究。

• 批准号: 07680109
• 负责人: KASUGA Norikatsu
• 金额: $ 1.22万
• 依托单位: AICH UNIVERSITY OF EDUCATION
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07680109/
• 关键词: SKELETAL MUSCLE INJURY; SKELETAL MUSCLE FIBER; DOWNHILL RUNNING; ENDPLATE; FIBER TYPE; 骨格筋; 筋崩壊

Muscle damage and/or injury generally occurs in response to the eccentric component of intense muscular activity. This study assumed that muscle fiber transformation is indicated by injury and experiment on determination whether this hypothesis is good or not.Skeletal muscle injury after downhill running was estimated from histochemical analysis of muscle cross-sections by determing the numbers of intact fibers per unit area in the muscle of rats. Two or three days after downhill running the tetanic tension by indirected stimulation was less than direct stimulate tension, and some endplates showed unfusimotor axons. Collateral and terminal sprouting were also seen in plantaris muscle after downhill running. Many of the reinnervated endplates were supplied by nerve branches from two or more different axons, and only gradullaly did this polyneuronal innervation subsided. A significant conversion of type IIb into type IIa fiber with nine weeks endurance training involved downhill running was observed.It is concluded that increases in muscle fiber transformation occur after downhill running induced injury and regeneration may have a role in the etiology of the neuromuscular junction injury process.

肌肉损伤和/或损伤通常响应于强烈肌肉活动的偏心分量而发生。本研究假设肌肉纤维的转化是由损伤和实验来确定这一假设是否正确，通过对大鼠肌肉横截面的组织化学分析，通过测定肌肉中单位面积上完整纤维的数量来估计下坡跑后骨骼肌的损伤。下坡跑后2 ~ 3天，间接刺激的强直张力低于直接刺激的强直张力，部分终板出现不融合运动轴突。下坡跑后跖肌侧支和终末出芽。许多再支配终板由两个或多个不同轴突的神经分支供应，这种多神经元的神经支配只是逐渐消退。一个显着的转换为Ⅱ a型纤维与9周耐力训练涉及下坡running.It的结论是，增加肌纤维转化后发生下坡运行引起的损伤和再生可能有一个作用的神经肌肉接头损伤过程的病因。

项目成果

春日規克,他: "骨格筋再生時の運動負荷と神経筋接合部の変化" 体力科学. 44. 640 (1995)

Norikatsu Kasuga 等人：“骨骼肌再生过程中的运动负荷和神经肌肉接头的变化”《体能科学》44. 640 (1995)。

NORIKATSU KASUGA,etal.: "CONTRACTILE PROPERTIES AND HISTOCHEMICAL STUDIE OF SUITED TRAINING FOR SKELETAL MUSCLE" JPN.J.BIOCHEM.EXERCISE. 7. 6-14 (1995)

NORIKATSU 春日等人：“骨骼肌训练的收缩特性和组织化学研究”JPN.J.BIOCHEM.EXERCISE。

春日規克,他: "運動負荷の実験のとらえ方-動物実験から-" 運動生化学. 7. 6-14 (1995)

Norikatsu Kasuga 等人：“如何理解运动负荷实验 - 来自动物实验 -”运动生物化学 7. 6-14 (1995)。

NORIKATSU KASUGA: "NEUROMUSCLAR JUNCTION MORPHOLOGICAL CHANGING IN INJURY MUSCLE DURING ENDURANCE TRAINING" JPN.J.PHYS.FIT.SPORTS MED.44. 640 (1995)

NORIKATSU KASUGA：“耐力训练期间受伤肌肉的神经肌肉连接形态变化”JPN.J.PHYS.FIT.SPORTS MED.44。

春日規克,他: "骨格筋再生時の運動負荷と神経筋接合部の変化" 体力科学. 44. 640- (1995)

Norikatsu Kasuga 等人：“骨骼肌再生过程中神经肌肉接头的运动负荷和变化”《体能科学》44. 640- (1995)。