Ultrastructural study of mechanism and prevention of the food allergy during suckling to weaning period.

哺乳期至断奶期食物过敏机制及预防的超微结构研究

基本信息

  • 批准号:
    14580155
  • 负责人:
  • 金额:
    $ 2.24万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2002
  • 资助国家:
    日本
  • 起止时间:
    2002 至 2005
  • 项目状态:
    已结题

项目摘要

We investigated that the structure of the small intestine and macromolecular uptake into the absorptive cells during postnatal development. The aim of this study was to elucidate the invasive pathway of food allergen and establish the preventive method of the food allergy during weaning process.In the neonatal-suckling rats, the absorptive cells of the small intestine endocytosed maternal milk macromolecules including antibodies from the lumen. Moreover, transcytosis was observed in the absorptive cells from the proximal small intestine. The digestive and absorptive system of the small intestine, however, greatly changed in the weaned rat. After weaning, the absorptive cells absorbed small molecules that were digested in the alimental canal and on the microvilli.In the neonatal-suckling period, feeding influenced the structure and function, especially macromolecular uptake, of the small intestinal absorptive cells. After 7days feeding, the structure and function of the absorptive cells varied with diet. Macromolecular uptake into the absorptive cells greatly differed between feeding on maternal milk and other diet.These results suggested that feeding on only maternal milk was preferable to prevent the food allergy. In case of impossible to feed on maternal milk, feeding on small molecule was better. After closed the transcytotic pathway, artificial milk and other diet should be fed. It seemed that feeding in the suckling-weaning period was important to prevent the food allergy.
本实验研究了小肠发育过程中的结构变化和小肠吸收细胞对大分子物质的吸收。本研究旨在阐明食物过敏原的侵入途径,建立断奶过程中食物过敏的预防方法。在哺乳期大鼠,小肠吸收细胞从小肠腔中摄取包括抗体在内的母乳大分子物质。此外,在近端小肠的吸收细胞中观察到转胞吞作用。但断奶后小肠的消化吸收系统发生了很大变化。断奶后,小肠吸收细胞吸收消化道和微绒毛上的小分子物质,哺乳期摄食影响小肠吸收细胞的结构和功能,尤其是大分子物质的吸收。摄食7 d后,不同饲料对吸收细胞的结构和功能有不同的影响。母乳喂养与其他食物喂养的大鼠吸收细胞对大分子物质的摄取量有很大差异,提示母乳喂养对预防食物过敏有一定的作用。在母乳无法喂养的情况下,以小分子奶粉喂养为佳。转胞吞途径关闭后,应喂人工奶和其他饲料。提示哺乳-断奶期喂养对预防食物过敏有重要意义。

项目成果

期刊论文数量(34)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Detection of a smaller, 32-kDa 8-oxoguanine DNA glycosylase 1 in 3,3'-methyl-4-dimethylamino-azobenzene-treated mouse liver.
在 3,3-甲基-4-二甲氨基-偶氮苯处理的小鼠肝脏中检测到较小的 32-kDa 8-氧代鸟嘌呤 DNA 糖基化酶 1。
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hirano T;Kudo H;Doi Y;Nishino T;Fujimoto S;Tsurudome Y;Ootsuyama Y;Kasai H.
  • 通讯作者:
    Kasai H.
Vasculogenesis and angiogenesis.
  • DOI:
    10.1007/978-1-4419-8871-3_1
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Sybill Patan
  • 通讯作者:
    Sybill Patan
Augmentation of intrarenal angiotensin II levels in uninephrectomized aldosterone/salt-treated hypertensive rats.
未肾切除醛固酮/盐治疗的高血压大鼠肾内血管紧张素 II 水平的升高。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Fan YY;Baba R;Nagai Y;Miyatake A;Hosomi N;Kimura S;Sun GP;Kohno M;Fujita M;Abe Y;Nishiyama A.
  • 通讯作者:
    Nishiyama A.
咀嚼・嚥下困難な人のための食事に関する研究-タンパク質分解酵素を利用した鶏肉の形態学的研究-
针对咀嚼和吞咽困难者的膳食研究 - 利用蛋白水解酶对鸡肉进行形态学研究 -
Yoshiaki DOI, Hideaki KUDO, Tomoko NISHINO, Sunao FUJIMOTO: "Vasculogenesis and angiogenesis"Journal of UOEH. 25・4. 409-417 (2003)
土井义明、工藤秀明、西野智子、藤本须直:“血管生成和血管生成”UOEH 杂志 25・4(2003 年)。
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
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FUJITA Mamoru其他文献

FUJITA Mamoru的其他文献

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{{ truncateString('FUJITA Mamoru', 18)}}的其他基金

Registration and Analysis of Oral Materials in the Aymara Language of the Southern Andes
安第斯山脉南部艾马拉语口述材料的登记和分析
  • 批准号:
    26870130
  • 财政年份:
    2014
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Nutritional management for primary prevention of food allergy based on changes of digestive and absorptive mechanism in sucklings and infants
基于乳婴消化吸收机制变化的食物过敏一级预防营养管理
  • 批准号:
    18500638
  • 财政年份:
    2006
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Ultrastructural and immunohistochemical studies on food allergy and intestinal barrier system
食物过敏与肠道屏障系统的超微结构和免疫组织化学研究
  • 批准号:
    09680048
  • 财政年份:
    1997
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Ultrastructural and immunohistochemical studies on endocytic pathway of high density lipoprotein (HDL) in cells.
细胞内高密度脂蛋白(HDL)内吞途径的超微结构和免疫组织化学研究。
  • 批准号:
    05670034
  • 财政年份:
    1993
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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  • 批准号:
    10590479
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    2023
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Breastmilk antibodies regulate neonatal immunity to the microbiota
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    10568623
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    2023
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Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogen
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    10693952
  • 财政年份:
    2021
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Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogen
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    10488196
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Epigenetic mechanisms of carcinogenesis by Parvimonas micra, an oral cavity commensal turned colon cancer pathogen
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早期环境、发育表观遗传学和成人结肠疾病
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    2020
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Development and evaluation of a high-fidelity newborn simulator for breastfeeding education of health professionals
用于卫生专业人员母乳喂养教育的高保真新生儿模拟器的开发和评估
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    10082009
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Early Environment, Developmental Epigenetics, and Adult Colonic Diseases
早期环境、发育表观遗传学和成人结肠疾病
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New strategy for the feeding control of suckling and weaning calves: coexistence of animal health, growth performance and forage feeding
哺乳牛和断奶牛犊饲养控制新策略:动物健康、生长性能和饲草饲喂并存
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    18K05959
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The impact of vitamin A on the gut-mammary gland-secretory IgA axis during enteric viral infections
肠道病毒感染期间维生素 A 对肠道-乳腺-分泌 IgA 轴的影响
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