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A neurobehavioral study of the attention-deficit/hyperactivity disorder (ADHD) model rat with an abnormal morphogenesis of the hippocampus or the cerebellum using

使用海马或小脑形态发生异常的注意力缺陷/多动障碍 (ADHD) 模型大鼠的神经行为研究

基本信息

批准号：
16530470
负责人：
SUGIOKA Kozo
金额：
$ 2.37万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

We examined the correlation of the behavioral disorders with the morphogenetical abnormality of the brain in the attention-deficit/hyperactivity disorder (AD/HD) model animals which were induced by methylazoxymethanol (MAM) injection on the prenatal 15-day (MAM-15 group) or 19-day (MAM-19 group). Behavioral results were following, 1) the MAM-15 rat showed a hyperactive tendency and the MAM-19 rat showed a hypoactive tendency, which were measured by infra-red sensor during dark phase in a home-cage, during both weaning and adult periods, 2) the MAM-15 rat showed a retardation of the habituation to the environmental visual stimulus changing, and 3) the MAM-15 rat showed a severe impaired spatial cognition (especially spatial working-memory deficit) in the radial-maze and the Morris-type water maze learning situations, although the MAM-19 rat showed a moderate deficit, during both developmental stages. The behavioral disorder observed in the MAM-15 rat correlated with a morphological abnormality of the hippocampus (disruption of the CA1 pyramidal layer and ectopic neuron mass), and the behavioral disorder, although which were moderate, observed in the MAM-19 rat correlated with an abnormal foliation of the anterior cerebellum. Our behavioral and histological results suggest that the AD/HD-like behavioral disorder obtained in the present study may be derived from the brain dysfunction induced by abnormal morphogenesis of the hippocampus.

我们检查了在产前15天（MAM-15组）或19天（MAM-19组）注射甲基偶氮甲醇（MAM）诱导的注意力缺陷/多动障碍（AD/HD）模型动物中行为障碍与大脑形态发生异常的相关性。行为结果如下，1) MAM-15 大鼠表现出多动倾向，而 MAM-19 大鼠表现出低动倾向，这是通过红外传感器在断奶期和成年期在家笼中的黑暗阶段通过红外传感器测量的，2) MAM-15 大鼠表现出对环境视觉刺激变化的适应迟缓，3) MAM-15 大鼠表现出严重的空间认知受损（尤其是尽管 MAM-19 大鼠在两个发育阶段都表现出中度缺陷，但在径向迷宫和莫里斯型水迷宫学习情况中存在空间工作记忆缺陷。在 MAM-15 大鼠中观察到的行为障碍与海马形态异常（CA1 锥体层破坏和异位神经元团）相关，而在 MAM-19 大鼠中观察到的行为障碍虽然中等，但与小脑前叶的异常叶状结构相关。我们的行为和组织学结果表明，本研究中获得的AD/HD样行为障碍可能源于海马形态发生异常引起的脑功能障碍。