A neurobehavioral study of the attention-deficit/hyperactivity disorder (ADHD) model rat with an abnormal morphogenesis of the hippocampus or the cerebellum using

使用海马或小脑形态发生异常的注意力缺陷/多动障碍 (ADHD) 模型大鼠的神经行为研究

基本信息

批准号：
16530470
负责人：
SUGIOKA Kozo
金额：
$ 2.37万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

We examined the correlation of the behavioral disorders with the morphogenetical abnormality of the brain in the attention-deficit/hyperactivity disorder (AD/HD) model animals which were induced by methylazoxymethanol (MAM) injection on the prenatal 15-day (MAM-15 group) or 19-day (MAM-19 group). Behavioral results were following, 1) the MAM-15 rat showed a hyperactive tendency and the MAM-19 rat showed a hypoactive tendency, which were measured by infra-red sensor during dark phase in a home-cage, during both weaning and adult periods, 2) the MAM-15 rat showed a retardation of the habituation to the environmental visual stimulus changing, and 3) the MAM-15 rat showed a severe impaired spatial cognition (especially spatial working-memory deficit) in the radial-maze and the Morris-type water maze learning situations, although the MAM-19 rat showed a moderate deficit, during both developmental stages. The behavioral disorder observed in the MAM-15 rat correlated with a morphological abnormality of the hippocampus (disruption of the CA1 pyramidal layer and ectopic neuron mass), and the behavioral disorder, although which were moderate, observed in the MAM-19 rat correlated with an abnormal foliation of the anterior cerebellum. Our behavioral and histological results suggest that the AD/HD-like behavioral disorder obtained in the present study may be derived from the brain dysfunction induced by abnormal morphogenesis of the hippocampus.

我们检查了注意缺陷/多动障碍（AD/HD）模型动物的行为障碍与大脑的形态学异常的相关性，这些动物是通过甲基夏友甲醇（MAM）注射在产前15天（MAM-15组）或19天（MAM-15组）或19天（MAM-19天组）上诱导的。行为结果遵循，1）MAM-15大鼠表现出过度活跃的趋势，MAM-19大鼠显示出低血球的趋势，在天笼中，在黑暗期间通过红外传感器在断奶和成人期间通过红外传感器进行测量，2）MAM-15均显示出对环境视觉刺激的习惯，并显示出对环境视觉刺激的习惯，并表现出AMAM-15的习惯。径向迷宫和莫里斯型水迷宫学习情况中的空间工作记忆赤字），尽管在两个发育阶段，MAM-19大鼠均表现出适度的赤字。在MAM-15大鼠中观察到的行为障碍与海马的形态异常相关（CA1锥体层的破坏和异位神经元质量的破坏）和行为障碍，尽管在MAM-9大鼠大鼠中观察到了中等程度的中等程度，但与MAM-9大鼠相关。我们的行为和组织学结果表明，在本研究中获得的AD/HD样行为障碍可以源自海马的异常形态发生引起的脑功能障碍。