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A neurobehavioral study of experimentally-induced model animals of attention-deficit hyperactive disorders (ADHD)

实验诱导的注意力缺陷多动障碍（ADHD）动物模型的神经行为研究

基本信息

批准号：
09610080
负责人：
SUGIOKA Kozo
金额：
$ 1.54万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

Studies were performed to determine the relation between the morphological abnormalities of the hippocampus and the behavioral indices in rats exposed to prenatal methylazoxymethanol acetate (MAM) or with neonatal hippocampal lesions, in attempts to produce a model of attention-deficit hyperactive disorders (ADHD). Rats were subjected to a open-field, a shuttle-box avoidance and a radial maze learning tests during weaning or adult period.Result were follows : 1) Rats treated MAM on the day 13 or 15 of gestation (G) showed hyperactivity at the weaning stage, but not at the adult period, 2) The G13 and G15 MAM rats showed a facilitated avoidance learning, whereas the G17 and G19 MAM rats showed a disability of avoidance learning compared to the controls, 3) The G13 and G15 MAM rats showed a learning deficit in the place-learning task but not in the cue-learning task on a 8-arm radial maze, 4) The G13 MAM rats showed an impairment of working memory when the retention interval was 10 min or more on a radial-arm maze retention task, 5) Rats lesioned the hippocampus on the day of birth showed a place-learning deficit on a 8-arm radial maze. Model animals which showed a hyperactivity, a facilitated avoidance and a spatial learning deficit in MAM rats tad mophological abnormalities of the hippocampus (occasional disruptions of the CAl pyramidal layer and/or numerous ectopic pyramidal neuron mass).These behavioral disorders seem to be similar to those in ADHD children. Our findings indicate that the ADHD syndrome might be caused by hippocampal dysfunction which was occurred during perinatal period.

通过研究产前暴露于甲基甲氧基乙酸甲醇（MAM）或新生儿海马病变大鼠海马形态异常与行为指标的关系，试图建立注意缺陷多动障碍（ADHD）模型。大鼠分别在断奶期和成人期进行空地、穿梭箱回避和径向迷宫学习测试。结果如下：老妈那天1)小鼠妊娠(G)的13 - 15显示多动症在断奶阶段,但不是在成年时期,2)G13和避免G15老妈小鼠表现出促进学习,而按照类型和老妈老鼠显示避免学习的残疾与对照组相比,3)G13 G15老妈小鼠表现出学习地点赤字记忆任务而不是cue-learning 8-arm径向迷宫,4) G13 MAM大鼠在8臂迷宫保留任务中，海马损伤大鼠在8臂迷宫保留任务中出现位置学习缺陷。模型动物在MAM大鼠中表现出过度活跃、易于回避和空间学习缺陷，并伴有海马的形态学异常（CAl锥体层偶尔中断和/或大量异位锥体神经元团块）。这些行为障碍似乎与多动症儿童相似。我们的研究结果表明，ADHD综合征可能是由围生期海马功能障碍引起的。