A neurobehavioral study of experimentally-induced model animals of attention-deficit hyperactive disorders (ADHD)

实验诱导的注意力缺陷多动障碍（ADHD）动物模型的神经行为研究

基本信息

批准号：
09610080
负责人：
SUGIOKA Kozo
金额：
$ 1.54万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

Studies were performed to determine the relation between the morphological abnormalities of the hippocampus and the behavioral indices in rats exposed to prenatal methylazoxymethanol acetate (MAM) or with neonatal hippocampal lesions, in attempts to produce a model of attention-deficit hyperactive disorders (ADHD). Rats were subjected to a open-field, a shuttle-box avoidance and a radial maze learning tests during weaning or adult period.Result were follows : 1) Rats treated MAM on the day 13 or 15 of gestation (G) showed hyperactivity at the weaning stage, but not at the adult period, 2) The G13 and G15 MAM rats showed a facilitated avoidance learning, whereas the G17 and G19 MAM rats showed a disability of avoidance learning compared to the controls, 3) The G13 and G15 MAM rats showed a learning deficit in the place-learning task but not in the cue-learning task on a 8-arm radial maze, 4) The G13 MAM rats showed an impairment of working memory when the retention interval was 10 min or more on a radial-arm maze retention task, 5) Rats lesioned the hippocampus on the day of birth showed a place-learning deficit on a 8-arm radial maze. Model animals which showed a hyperactivity, a facilitated avoidance and a spatial learning deficit in MAM rats tad mophological abnormalities of the hippocampus (occasional disruptions of the CAl pyramidal layer and/or numerous ectopic pyramidal neuron mass).These behavioral disorders seem to be similar to those in ADHD children. Our findings indicate that the ADHD syndrome might be caused by hippocampal dysfunction which was occurred during perinatal period.

进行了研究以确定暴露于产前甲基甲醇乙醇酯（MAM）的大鼠的形态异常与行为指数之间的关系，或与新生儿海马病变相关，以产生引起缺乏注意力缺陷的多动态性异常模型（ADHD）。 Rats were subjected to a open-field, a shuttle-box avoidance and a radial maze learning tests during weaning or adult period.Result were follows : 1) Rats treated MAM on the day 13 or 15 of gestation (G) showed hyperactivity at the weaning stage, but not at the adult period, 2) The G13 and G15 MAM rats showed a facilitated avoidance learning, whereas the G17 and G19 MAM rats showed a disability of avoidance learning compared to the controls, 3) The G13 and G15 MAM rats showed a learning deficit in the place-learning task but not in the cue-learning task on a 8-arm radial maze, 4) The G13 MAM rats showed an impairment of working memory when the retention interval was 10 min or more on a radial-arm maze retention task, 5) Rats lesioned the hippocampus on出生的日子显示出8臂径向迷宫上的地方学习赤字。模型动物表现出多动症，促进的回避和妈妈大鼠的空间学习缺陷，tad乳状体学异常（偶尔会造成Cal pyramidal层的中断和/或许多异位金字化神经元质量）。我们的发现表明，ADHD综合征可能是由于围产期期间发生的海马功能障碍引起的。