Chemical Sensor and Biosensor based on carbon nanotube modified with molecular receptors

碳纳米管（CNTs）独特的电子、化学和机械性能使其对化学和生化传感器极具吸引力。初步研究表明，碳纳米管具有快速的电子转移动力学和浓度函数，可以作为生物传感器的优良换能器。低分子量酶如辣根过氧化物酶（HRP）和微过氧化物酶（MP-11）被物理吸附到纳米管电极上。结果表明，基于酶解酶的纳米管生物传感器对过氧化氢具有较高的敏感性，而基于mp -11的纳米管生物传感器具有非常稳定的重复使用性能。此外，葡萄糖氧化酶与纳米管共价键合制备的葡萄糖传感器在苯醌作为电化学介质存在的情况下对葡萄糖敏感。此外，冠状、环糊精和环多胺修饰的纳米管电极分别对儿茶酚胺、双酚A和二碳酸化合物有敏感反应，并具有基于宿主相互作用的浓度函数。

The unique electronic, chemical and mechanical properties of carbon nanotubes (CNTs) make them extremely attractive for chemical and biochemical sensors. Preliminary studies demonstrated that CNTs have fast electron-transfer kinetics and concentration function suggesting that they may serve as excellent transducers for biosensors.Low molecular weight enzymes such as horseradish peroxidase (HRP) and microperoxidase (MP-11) were physically adsorbed onto the nanotube electrode. As a result, HRP-based nanotube biosensor responded to hydrogen peroxide with high sensitivity, while MP-11-based nanotube biosensor was very stable for its repeated use. Also, glucose sensor prepared by covalent bonding of glucose oxidase into the nanotube responded sensitively to glucose in the presence of benzoquinone as an electrochemical mediator. Furthermore, nanotube electrodes modified with crown, cyclodextrine, and cyclic polyamine responded sensitively to catecholamine, bisphenol A, dicarbonic acid compounds, respectively, with some concentration functions based on the host-gest interactions.