NEBULIZATION TECHNIQUE FOR AEROSOLIZATION OF PENTAMIDINE

喷他脒雾化的雾化技术

• 批准号: 3837937
• 负责人: F P OGNIBENE
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3837937
• 关键词: Pneumocystis; Pneumocystis pneumonia; diagnostic respiratory lavage; drug tolerance; human subject; pentamidine; radionuclide imaging /scanning; respiratory disorder chemotherapy; technology /technique

Although aerosolized pentamidine is effective in limiting the occurrence of Pneumocystis carinii (PC) pneumonia, its use may actually be associated with preferentially manifested upper lobe pneumonia due to PC. This may be a function of the pattern of lung distribution of pentamidine by the conventional (Respirgard II) nebulizer. In this pilot study, tolerance of a new nebulizer (Babington model) will be assessed and compared with the conventional nebulizer. In addition, there will be an attempt to quantify pentamidine distribution geographically, using nuclear medicine scanning techniques and chemically, using bronchoalveolar lavage analysis. The goal of this prospective study is to determine the mode of nebulization that most effectively allows for equal pulmonary distribution of the drug, and, in doing so, is best tolerated by the patient. Efficacy is not being addressed in this study.

虽然喷他脒雾化可以有效地限制 卡氏肺孢子虫（PC）肺炎，它的使用实际上可能是 与上叶肺炎的优先表现有关， PC. 这可能是肺分布模式的函数， 喷他脒常规（Respirgard II）雾化器。 在这 初步研究，新雾化器（Babington型号）的耐受性将 并与传统雾化器进行比较。 此外，本发明还提供了一种方法， 将尝试量化喷他脒分布 在地理上，使用核医学扫描技术， 化学上，使用支气管肺泡灌洗分析。 这个目标 前瞻性研究是为了确定雾化方式， 有效地允许药物在肺部均匀分布， 这样做，患者最能耐受。 有效性不是 在这项研究中解决。