NEBULIZATION TECHNIQUE FOR AEROSOLIZATION OF PENTAMIDINE

虽然雾化喷雾剂能有效地限制这种情况的发生 卡氏肺孢子虫(PC)肺炎，其用途实际上可能是 与优先表现的上叶肺炎相关，原因是 PC机这可能是肺组织分布模式的一个函数。 用传统的(Respirgard II)雾化器喷雾器喷雾。在这 试点研究，一种新的雾化器(巴宾顿模型)的耐受性将是 评估并与常规雾化器进行了比较。此外, 将尝试量化五烷双胺的分布 在地理上，使用核医学扫描技术和 化学上，使用支气管肺泡灌洗液分析。这样做的目的是 前瞻性研究是确定雾化方式最多的 有效地允许药物在肺内均匀分布，并且在 这样做是患者最好的耐受性。药效不是 在这项研究中提到的。

Although aerosolized pentamidine is effective in limiting the occurrence of Pneumocystis carinii (PC) pneumonia, its use may actually be associated with preferentially manifested upper lobe pneumonia due to PC. This may be a function of the pattern of lung distribution of pentamidine by the conventional (Respirgard II) nebulizer. In this pilot study, tolerance of a new nebulizer (Babington model) will be assessed and compared with the conventional nebulizer. In addition, there will be an attempt to quantify pentamidine distribution geographically, using nuclear medicine scanning techniques and chemically, using bronchoalveolar lavage analysis. The goal of this prospective study is to determine the mode of nebulization that most effectively allows for equal pulmonary distribution of the drug, and, in doing so, is best tolerated by the patient. Efficacy is not being addressed in this study.