Research on carcinogenesis modifying factor by static magnetic field exposure

静磁场暴露致癌调节因子的研究

基本信息

  • 批准号:
    16590486
  • 负责人:
  • 金额:
    $ 2.24万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2004
  • 资助国家:
    日本
  • 起止时间:
    2004 至 2006
  • 项目状态:
    已结题

项目摘要

We have previously found that exposure to static magnetic fields (SMFs) increase the frequency of micronuclei. In this experiment, it became clear that co-exposure to SMFs increases the frequency of micronuclei induction by several mutagens including active oxygen radical inducible chemicals (doxorubicin (DOX), mitomycin C (MMC)). Therefore, the increase in micronucleus formation by SMFs might be related to active oxygen radical inducibility. In the present study, we used the mouse bone marrow micronucleus test to investigate whether antioxidant (ascorbic acid (AS)) can control the effects of SMF co-exposure on the frequency of micronuclei produced by radical-inducing chemicals. As a result, the following were clarified.1)As itself did not induce any micronuclei.2)Frequency of micronuclei by DOX or MMC increased by exposure to 5 T SMFs.3)Frequency of micronuclei induced by both DOX and MMC was increased by co-exposure to SMFs, but these increases were blocked by pretreatment with ascorbic acid.4)Frequency of micronuclei induced by co-exposure to MMC and SMFs decreased strongly at 20 min interval of ascorbic acid pre-treatment.5)Effect of ascorbic acid on the micronucleus frequency was maintained for at least 72 hours.6)Increased levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in bone marrow cells was observed after exposure to SMFs.These results suggest that SMFs exposure triggers the induction of mutagen-related radicals. This effect might increase the micronucleus frequency.
我们以前发现,暴露于静磁场(SMF)增加微核的频率。在该实验中,很明显,共同暴露于SMF会增加几种诱变剂(包括活性氧自由基诱导化学品(多柔比星(DOX)、丝裂霉素C(MMC)的微核诱导频率。因此,SMFs引起的微核形成增加可能与活性氧自由基诱导有关。在本研究中,我们使用小鼠骨髓微核试验,以探讨抗氧化剂(抗坏血酸(AS))是否可以控制SMF的共同暴露的自由基诱导化学品产生的微核频率的影响。结果表明:1)As本身不诱导任何微核; 2)5 T SMF暴露增加DOX或MMC的微核率; 3)SMF联合暴露增加DOX和MMC诱导的微核率,但这种增加被抗坏血酸预处理所阻断。抗坏血酸预处理20 min后,MMC和SMF的微核率显著降低。5)抗坏血酸对微核率的影响可维持至少72 h。6)8-羟基脱氧鸟苷(8-OHdG)水平升高。这些结果表明,SMFs的暴露触发了诱变剂相关自由基的诱导。这种效应可能会增加微核率。

项目成果

期刊论文数量(26)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The frequencies of micronuclei induced by cisplatin in newborn rat astrocytes are increased by 50-Hz, 7.5-and 10-mT electromagnetic fields
A study of the health effects and electro magnetic fields.
对健康影响和电磁场的研究。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    K.Asanuma;T.Agata;Y.Nakamura;S.Naruse;Y.Suzuki;H.Shimizu
  • 通讯作者:
    H.Shimizu
Effects of Magnetic Field on Biological Systems.
磁场对生物系统的影响。
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    M.Ikehata;T.Kawasaki;Y.Suzuki;H.Shimizu;T.Koana
  • 通讯作者:
    T.Koana
Fifty-hertz electromagnetic fields increase the frequencies of micronuclei induced by 5-fluorouracil in newborn rat astrocytes.
50 赫兹电磁场增加新生大鼠星形胶质细胞中 5-氟尿嘧啶诱导的微核频率。
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Inoue;K. et al.;大神 明;Ono Y;Tomohiro Kitamura;Yuichi Miyakoshi 他
  • 通讯作者:
    Yuichi Miyakoshi 他
Effects of static magnetic fields on the induction of micronuclei by some mutagens. Environ.
静磁场对某些诱变剂诱导微核的影响。
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

SUZUKI Yuji其他文献

SUZUKI Yuji的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('SUZUKI Yuji', 18)}}的其他基金

Analyses on Environmental Behavior of Perfluorinated Compounds including Their Formation Potentials from Precursors
全氟化合物的环境行为包括前体形成潜力的分析
  • 批准号:
    16K21123
  • 财政年份:
    2016
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Improvement of photosynthetic capacity by an enhancement of ATP synthesis in rice
通过增强水稻 ATP 合成来提高光合作用能力
  • 批准号:
    22780055
  • 财政年份:
    2010
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Enhancement of Rubisco content of rice leaves by an overexpression of rbcS
通过 rbcS 的过度表达提高水稻叶片的 Rubisco 含量
  • 批准号:
    19780047
  • 财政年份:
    2007
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
On Chemical Quenching Mechanisms in Microscale Combustion
微尺度燃烧中的化学淬火机理研究
  • 批准号:
    19360094
  • 财政年份:
    2007
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Basic development research on seismic electret power generation system with micro combustion engine
微型内燃机地震驻极体发电系统基础开发研究
  • 批准号:
    17360092
  • 财政年份:
    2005
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Flow and Heat Transfer Characteristics of Hydrophobic and Hydrophilic Microchannel Flow
疏水和亲水微通道流动的流动和传热特性
  • 批准号:
    16560174
  • 财政年份:
    2004
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A new method for evaluation of neurotoxicological chemicals
神经毒理学化学物质评价的新方法
  • 批准号:
    13670344
  • 财政年份:
    2001
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Basic Study on Active-Feedback Control of Non-Linear Heat and Fluid Flow
非线性热量和流体流动主动反馈控制的基础研究
  • 批准号:
    10555055
  • 财政年份:
    1998
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
A NEW NEUROTOXICOLOGICAL TEST SYSTEM USING NERVE CELL LINE
使用神经细胞系的新型神经毒理学测试系统
  • 批准号:
    10670366
  • 财政年份:
    1998
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of Microchannel Heat Exchanger for Refrigeration
制冷用微通道换热器的研制
  • 批准号:
    09555071
  • 财政年份:
    1997
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)

相似海外基金

Analysis of the antioxidant function of xCT in lymphatic endothelial cells and its significance in oral squamous cell carcinoma.
淋巴管内皮细胞xCT抗氧化功能分析及其在口腔鳞癌中的意义
  • 批准号:
    23K16139
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Transcriptional Activation of p62 by the master antioxidant NRF2 in EBV latency
EBV潜伏期主要抗氧化剂NRF2对p62的转录激活
  • 批准号:
    10726975
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
Mitochondria-targeted antioxidant supplementation for improving age-related vascular dysfunction in older adults: the role of circulating factors
线粒体靶向抗氧化剂补充剂可改善老年人与年龄相关的血管功能障碍:循环因子的作用
  • 批准号:
    10606926
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
NAD(P)H quinone oxidoreductase 1 (NQO1)-mediated bypass of mitochondrial electron transport chain with artificial and endogenous substrates
NAD(P)H 醌氧化还原酶 1 (NQO1) 介导的人工和内源底物线粒体电子传递链旁路
  • 批准号:
    10789749
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
Biology the initiator: Harnessing Reactive Oxygen Species for Biocompatible Polymerization
生物学引发者:利用活性氧进行生物相容性聚合
  • 批准号:
    10667740
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
CAREER: Oligomeric Stoichiometry of Superoxide Dismutase 1 and Neuronal Antioxidant Defense
职业:超氧化物歧化酶 1 的寡聚化学计量和神经元抗氧化防御
  • 批准号:
    2237129
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Continuing Grant
Development of a new class of BLVRB-targeted redox therapeutics in breast cancer
开发一类新型 BLVRB 靶向乳腺癌氧化还原疗法
  • 批准号:
    10759653
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
Racial disparities of open angle glaucoma: A study of mitochondria and oxidative stress in human trabecular meshwork
开角型青光眼的种族差异:人类小梁网线粒体和氧化应激的研究
  • 批准号:
    10735655
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
Impact of obesity on chemotherapy-induced muscle mitochondrial dysfunction
肥胖对化疗引起的肌肉线粒体功能障碍的影响
  • 批准号:
    10752436
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
Role of Oral Microbiota on Vascular Function
口腔微生物群对血管功能的作用
  • 批准号:
    10628184
  • 财政年份:
    2023
  • 资助金额:
    $ 2.24万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了