Basic Study on Active-Feedback Control of Non-Linear Heat and Fluid Flow

非线性热量和流体流动主动反馈控制的基础研究

• 批准号: 10555055
• 负责人: SUZUKI Yuji
• 金额: $ 4.03万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10555055/
• 关键词: Coronary Artery; 3-D Reconstruction; Blood Flow Measurement; Ultra Sound Sensor; Catheter; Blood Flow Analysis Model; X-Ray Angiography; 電気回路モデル; 末梢抵抗; 心筋内血管; 自律神経系

A blood flow analysis model has been developed by using an analogy to an electric circuit. Flow resistance of peripheral coronary blood vessel is evaluated based on its anatomical feature having a fractal structure, and incorpolated into the model. Non-linear elasticity of blood vessel wall is also taken into account. The wave forms of flow rate and blood pressure given by the present model are in accordance with the clinical data. Local blood flow and pressure was measured in-vivo by using micro pressure sensor and ultra sound flow sensor. The amount of dataset is somewhat insufficient at this momonet, but the reliability of the measurement is verified.Three-dimensional reconstruction of coronary artery by using X-Ray angiography image data is examined, and preliminary test is made in order to develop blood flow analysis model based on clinical angiography.According to the knowledge from clinical cases of breast sympathectomy(experimental results by Dr.Tedoriya and collaborators), in order to describe the state of cardiovascular autonomic nervous system, that is controlled by heart pulse fluctuation and hormone balance, with stochastic models, we investigate the possibility of applying the covariance structure analysis and the independent component analysis, whose aim is to find important factors from observed data. Particularly, we studied theoretical aspect of testing for independence of factors which are obtained by those analysis.

一个血液流动分析模型已被开发，通过使用一个电路的类比。基于冠状动脉血管的分形结构特征，计算了冠状动脉血管的流动阻力，并将其引入模型中。血管壁的非线性弹性也被考虑在内。该模型给出的流速和血压波形与临床数据相符。利用微型压力传感器和超声流量传感器在体测量局部血流和压力。本课题在数据量上存在一定的不足，但验证了测量结果的可靠性，并对利用X射线血管造影图像数据进行冠状动脉的三维重建进行了研究，为建立基于临床血管造影的血流分析模型进行了初步的试验，根据乳腺交感神经切除术的临床病例知识，（Tedoriya博士和合作者的实验结果），为了用随机模型描述由心脏脉搏波动和激素平衡控制的心血管自主神经系统的状态，本文探讨了协方差结构分析和独立成分分析的可能性，其目的是从观测数据中找出重要因素。特别是，我们研究了理论方面的测试的独立性的因素，这是通过这些分析。